Biochem Biophys Res Commun 446:98 (2014)
Effects of miR-31 on the osteogenesis of human mesenchymal stem cells.
Xie Q1, Wang Z1, Bi X1, Zhou H1, Wang Y1, Gu P2, Fan X3.
Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem
cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related
diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The
overexpression of miR-31 repressed the osteogenesis of hMSCs, whereas the downregulation
enhanced this process. SATB2 was testified to be a direct target of miR-31, and its effects on
the osteogenesis were also described. Most importantly, the knockdown of SATB2 attenuated
miR-31's osteogenic effects. Taken together, our findings suggest that miR-31 regulates the
osteogenesis of hMSCs by targeting SATB2.