Biochem Biophys Res Commun 446:98 (2014)

Effects of miR-31 on the osteogenesis of human mesenchymal stem cells.

Xie Q1, Wang Z1, Bi X1, Zhou H1, Wang Y1, Gu P2, Fan X3.


摘要:

Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem
cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related
diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The
overexpression of miR-31 repressed the osteogenesis of hMSCs, whereas the downregulation
enhanced this process. SATB2 was testified to be a direct target of miR-31, and its effects on
the osteogenesis were also described. Most importantly, the knockdown of SATB2 attenuated
miR-31's osteogenic effects. Taken together, our findings suggest that miR-31 regulates the
osteogenesis of hMSCs by targeting SATB2.

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