小鼠趋化因子CXCL16 (CXCL16) (Murine)

CXCL16(Murine) 小鼠趋化因子CXCL16 (CXCL16) (Murine) MECXP-1601
产品货号: MECXP-1601
产品规格:
价格:


产品描述:
CXCL16 (CXC chemokine 16) is a nonELR motifcontaining CXC chemokine with a transmembrane domain. CX3CL1/Fractalkine and CXCL16 are the only two transmembrane chemokines within the superfamily. Mouse CXCL16 cDNA encodes a 246 amino acid residues (a.a.) precursor protein with a putative 26 a.a. residues signal peptide,an 88 a.a. residues chemokine domain, an 87 a.a. residues mucinlike spacer region, a 22 a.a. residue transmembrane domain, and a 23 a.a. residues cytoplasmic tail. Mouse and human CXCL16 share 49% overall a.a. identity and 70% similarity in the chemokine domains. Mouse CXCL16 is produced by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membranebound and soluble forms. Based on northern blot analysis, CXCL16 is also expressed in some nonlymphoid tissues such as lung, small intestine and kidney. The receptor for CXCL16 has been identified as CXCR6/Bonzo (STRL33 and TYMSTR), a receptor previously shown to be a coreceptor for HIV entry. CXCR6 is expressed on naive CD8 cells, natural killer T cells and activated CD8 and CD4 T cells.


表达系统 :
Escherichia coli


溶解方法:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.


产品组成:
Lyophilized from a 0.2 μm filtered concentrated solution in PBS.


存储条件:
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.


分子量:
Approximately 9.9 kDa, a single non-glycosylated polypeptide chain containing 88 amino acids.


内毒素:
Less than 1 EU/μg of CXCL16 as determined by LAL method.


产品用途:
This material is offered by Cyagen Biosciences for research, laboratory or further evaluation purposes. FOR RESEARCH USE ONLY. NOT INTENDED FOR ANY ANIMAL OR HUMAN THERAP EUTIC OR DIAGNOSTIC USE.


生物学活性:
The biologically active determined by a chemotaxis bioassay using murine lymphocytes is in a concentration of 20-1000 ng/mL.


产品形态:
Sterile filtered white lyophilized (freeze-dried) powder.


氨基酸序列:
NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP


产品纯度:
> 98% by SDS-PAGE and HPLC analyses.