BAC Transgenesis
BAC (Bacterial Artificial Chromosome) transgenesis enables insertion of large genomic fragments—such as full genes with regulatory elements—into rodent genomes, ensuring faithful expression and supporting complex loci that are hard to replicate by other methods.
Suited for Complex Targets
Optimized for full-length human genes and loci with complex control regions.
Large Fragment Delivery
Deliver fragments up to 300 kb, preserving key regulatory elements for accurate gene expression.
Genetic Stability
Single-copy maintenance in bacteria ensures construct integrity and stable transmission.
Technology
Applications
FAQs
How BAC Transgenesis Works
BAC transgenesis involves injecting bacterial artificial chromosome
constructs into fertilized zygotes. These BACs carry large genomic
regions—including promoters, exons, introns, and enhancers—enabling
expression patterns that closely mimic native gene regulation. Because
the integration is random and multicopy, BAC models are typically
screened for expression and copy number.
Note: Compared to knockin strategies using homologous
recombination or gene editing, BAC transgenesis allows introduction of
entire genes without modifying endogenous loci—making it ideal for
exploratory or overexpression studies.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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