Neurology CRO Services
Cyagen provides one-stop neuroscience CRO solutions from custom animal model generation to behavioral and molecular efficacy evaluation, enabling precise, rapid, and reliable preclinical research.
One-Stop Neuroscience CRO Solutions
Cyagen’s integrated neuroscience research platform provides specialized genetically
engineered and induced animal models, precise drug delivery, and comprehensive behavioral, pathological, and
molecular analyses. With over 2,000 validated neuroscience models and a proven track record supporting
publications in top journals, we streamline your research from discovery to therapeutic validation—accelerating
breakthroughs in Alzheimer’s, Parkinson’s, ALS, and other neurological disorders.
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Explore Cyagen’s neuroscience model portfolio across Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, blood-brain barrier research, and neuropathic pain, including humanized, genetic, and disease-relevant induced models.
Neurology
Research Models
Research Models
Alzheimer's Disease
HUGO-GT™ Models
- huTau (MAPT)
- B6-htau*P301L
Other Disease Models
- B6-APOE4/htau
- APP/PSEN1 Models
Induced Models
- AAV-Induced AD (APP/PSEN1)
Explore models→
Parkinson's Disease
Humanized Models
- B6-hSNCA
- B6-huTFRC/huSNCA (3'UTR)
Induced Models
- AAV-Induced Mouse PD Model
- α-Syn PFF-Induced Model
- 6-OHDA-Induced Model
- MPTP-Induced Model
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Huntington's Disease
Featured HD Models
- FVB-hHTT Q150 KI
- hHTT-Q150 (B6;FVB)
- hHTT-Qn(FVB)
- B6-huMSH3
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Blood-Brain Barrier
BBB Target Models
- hTFRC
- hIGF1R
Disease-Crossed Models
- huTFRC/htau
- huTFRC/huSNCA (3'UTR)
- hIGF1R/huTFRC/huCD98HC
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Neuropathic Pain
Humanized Target Models
- B6-hSCN9A
- hSCN10A (Nav1.8) SD Rat
Induced Models
- Chronic Constriction Injury (CCI)
- Spinal Nerve Ligation (SNL)
- Cisplatin-Induced Pain Model
Explore models→
Explore Induced and Surgical Models
Cyagen provides a range of induced and surgical models for neuroscience research. These models
reproduce disease-relevant neurological phenotypes through viral vector delivery, neurotoxin
exposure, nerve injury, and other established induction methods, supporting mechanistic studies and
preclinical efficacy evaluation across neurodegenerative diseases and neuropathic pain.
| Related Diseases | Modeling Method | Strain Background |
|---|---|---|
| Alzheimer’s Disease (AD) | AAV-Induced Mouse AD Model (APP/PSEN1) | Mouse |
| Parkinson’s Disease (PD) | AAV-Induced Mouse PD Model (AAV9.CNS-Mut-CAG-hαSyn-A53T) | Mouse |
| Parkinson’s Disease (PD) | 6-OHDA-Induced PD Model | Mouse & SD Rat |
| Parkinson’s Disease (PD) | α-Synuclein PFF-Induced Model [WT or hSNCA (3'UTR) + PFF] | Mouse |
| Parkinson’s Disease (PD) | Acute MPTP-Induced Model | Mouse |
| Parkinson’s Disease (PD) | Subacute MPTP-Induced Model | Mouse |
| Neuropathic Pain | Chronic Constriction Injury (CCI) Model | Mouse |
| Neuropathic Pain | Spinal Nerve Ligation (SNL) Rat Model | SD Rat |
| Neuropathic Pain | Cisplatin-Induced Peripheral Neuropathy Mouse Model | Mouse |
| Depression | Chronic Unpredictable Mild Stress (CUMS) Model | Mouse |
Model Selection Made Simple
Base Strain
Search for Models
| Catalog Number | Name | Base Strain | Research Application | Action |
|---|---|---|---|---|
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Looking for a custom disease model not listed in our database?
Our scientific team can develop or adapt models to fit your study requirements.
Request a
Custom Model
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Cyagen provides precise, customizable in vivo drug administration services designed
specifically for neuroscience research. Our expert technical team ensures accurate and reproducible
drug delivery directly to targeted brain and spinal regions, verified through rigorous imaging and
protein expression analyses.
Administration Methods Include:
- Stereotactic brain injection
- Stereotactic brain injection
- Intracerebroventricular (ICV) injection
- Intravenous (tail vein) injection
- Additional routes: Intranasal, intramuscular, subcutaneous, intraperitoneal, and more
Need Customized Administration for Your Project?
Case Examples:
1. Precise Brain Region Targeting (Stereotactic Injection)
- Injected Substance: AAV9-CMV-EGFP-HGH
- Titer: 1.98×10¹⁴ vg/mL
- Dose: 1×10¹¹ vg/0.5μL per injection
- Injection Coordinates: -2mm, ±1.8mm, -1.5mm
- Validation: Clear GFP expression 4 weeks post-injection, demonstrating accuracy and successful delivery.
Figure 8. Imaging demonstrates accurate
stereotactic delivery and localized expression of target protein.
2. Precise Brain Region Targeting (Stereotactic Injection)
- Injected Substance: AAV9-CMV-EGFP-HGH / AAV9-CAG-EGFP
- Titer & Dose: 4×10¹¹ vg (CMV); 1×10¹¹ vg (CAG)
- Injection Site: Lumbar vertebrae L4-L5
- Injection Coordinates: -2mm, ±1.8mm, -1.5mm
- Validation: Robust protein expression observed at 2 weeks post-injection, confirming effective intrathecal drug delivery.
Figure 9. Clear GFP signal indicates successful intrathecal injection and
target protein expression.
● Case Study 3
AAV9-CMV-EGFP-HGH
Coordinates: -2 mm, ±1.8 mm, -1.5 mm
Injection Titer: 1.98×10¹⁴ vg/mL
Dose: 1×10¹¹ vg/0.5 μL/site
Imaging Time: 4 weeks post-injection
White light imaging of brain
section
(Note: Stained with Toluidine blue, only showing the injection
location)
Fluorescence imaging of brain
section
Figure 10. Precise injection site visualization using the brain
stereotactic
instrument.
● Case Study 4
Lipopolysaccharide Injection
Coordinates: +4.8 mm, ±1.8 mm, -8.0 mm
Concentration: 5 mg/mL
Dose: 4 μL/site
Imaging Time: 2 weeks post-injection
Rat brain stereotactic positioning
injection schematic diagram
Observation: Rat displaying unidirectional
rotational movement 14 days post-operation.
Figure 11. Significant behavioral changes observed 2 weeks post-injection.
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Cyagen’s neuroscience CRO platform provides comprehensive and reliable evaluations
covering behavioral assessments, pathology, molecular biology, and pharmacological analyses. Our
internationally standardized assays enable accurate and reproducible measurement of neurological
outcomes and therapeutic efficacy, supporting researchers worldwide from preclinical validation to
clinical translation.
Behavioral Assays
- Morris Water Maze
- Y Maze
- Rotarod
- Open Field Test (OFT)
- Novel Object Recognition Test (NORT)
- Elevated Plus Maze (EPM)
- Forced Swimming Test (FST)
- Grip Strength Test
- Social Interaction Tests
- Treadmill & Balance Beam Test
- Tail Suspension Test and more
Pathological Analysis
- Tissue preparation and sectioning
- H&E staining
- Immunohistochemistry (IHC)
- Immunofluorescence staining (IF)
- Special staining techniques
- Fluorescent imaging & biomarker detection
- Apoptosis and proliferation analysis
Biochemical Analysis
- Quantitative PCR (qPCR)
- RT-PCR, Southern blot
- Western blot & ELISA
- Protein expression and localization
- Biomarker profiling
- Cytokine and inflammatory marker analysis
- Primer design & RNA extraction
Need Tailored Phenotypic & Efficacy Evaluations for Your Study?
● Multifunctional Neurobehavioral Assessment
Figure 12. A comprehensive panel of behavioral tests for multifunctional
neurobehavioral assessment.
Our Unique Advantages
Extensive & Validated Model Library
Rapid access to over 2,000 validated neuroscience mouse models, including KO, cKO, and HUGO-GT™ humanized models—ready-to-use within 48 hours to jumpstart your research.
Precise Drug Delivery & Reliable Results
Our skilled specialists perform targeted in vivo drug administration to precise CNS regions, with rigorous validation to guarantee reproducible and accurate data.
Comprehensive & Customizable Analysis
International-standard neurobehavioral testing paired with molecular, biochemical, and pathological analyses—fully supported by senior neuroscience experts.
Related Resources
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Blogs & Insights
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Resource Vault
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