Preclinical Oncology CRO Services
Cyagen provides end-to-end oncology CRO services – from advanced animal models to comprehensive drug evaluation and translational insights. Our platform accelerates oncology research with customizable models and validated preclinical solutions.
One-Stop Oncology CRO Solutions
As one of the leading preclinical oncology CRO companies, Cyagen provides comprehensive preclinical CRO solutions for oncology drug evaluation, supporting antibody drugs,
cell and gene therapies, mRNA-based approaches, and more. Our platform covers the full workflow — from diverse
tumor model generation (CDX, PDX, GEM, syngeneic, humanized) to in vivo efficacy studies and in vitro
mechanistic assays. With extensive experience across 200+ oncology projects and support for IND applications, we
help biopharma teams accelerate their oncology pipelines with confidence and precision.
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Discover our extensive collection of genetically engineered, xenograft, and humanized mouse models developed to support oncology research. Each model is validated for reliability and available for direct inquiry or customization to meet your study needs.
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Cyagen delivers comprehensive in vivo efficacy evaluation services that simulate clinical settings with high fidelity. From tumor establishment to pharmacodynamic monitoring, our platform supports a wide spectrum of model types and therapeutic modalities—helping clients generate robust, IND-enabling preclinical data.
Customized Study Design
Designs tailored for evaluating mAbs, mRNA drugs, CAR-T/NK therapies, oncolytic viruses, and
immune checkpoint inhibitors.
- IND-ready timelines & professional consultation included.
Tumor Model Flexibility
Supports subcutaneous, orthotopic, hematologic, and metastatic tumor models using:
- CDX (Cell-Derived Xenograft)
- PDX (Patient-Derived Xenograft)
- GEMM (Genetically Engineered Mouse Models)
- Humanized Immune Mouse Models (e.g., huHSC-C-NKG-ProF)
Endpoints & Technologies
- Tumor volume, body weight, survival ging (bioluminescence/fluorescence)
- Flow cytometry, H&E, IHC, ELISA, qPCR
- Customized readouts for mechanism-of-action or resistance studies
Need Customized Evaluation for Your Therapy?
Case Examples
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Cyagen offers a full suite of in vitro and ex vivo pharmacology services to support oncology drug discovery and mechanistic studies. These assays complement in vivo models, providing high-throughput, reproducible insights into drug cytotoxicity, immune activation, target interaction, and biomarker profiles.
Cytotoxicity & Immune Function Assays
- LDH / CTG / CCK-8 viability and cytotoxicity tests
- CAR-T/NK-mediated cell killing & activation
- T/NK cell cytokine secretion and proliferation
- Antibody-dependent cellular cytotoxicity (ADCC)
Molecular & Biomarker Detection
- Western Blot, ELISA, qPCR for expression profiling
- Cytokine panels via Singleplex (ELISA) and Multiplex (Luminex, MSD, FACS CBA)
- DNA/RNA detection via digital PCR and molecular hybridization
Histology & Imaging-Based Analysis
- H&E staining, immunohistochemistry (IHC)
- Immunofluorescence (IF), dual/multiplex labeling
- Fluorescence imaging for tissue localization & distribution
- In vivo biodistribution via IVIS if applicable
Pharmacokinetics & Toxicity (Optional add-on)
- Single or repeat dose toxicity testing
- Genotoxicity, reproductive toxicity, carcinogenicity
- Blood chemistry, organ indices, LC-UV bioanalysis
Looking to Validate Drug Mechanisms or Biomarkers?
Case Examples
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Our Unique Advantages
Broad Model Coverage for Translational Relevance
Cyagen provides one of the industry’s most extensive tumor model libraries—ranging from CDX, PDX, GEMM, to fully humanized immune mice—enabling clinically relevant assessments for diverse oncology pipelines.
End-to-End Evaluation from Efficacy to Mechanism
From tumor growth curves to biomarker analysis, we support every stage of your study with comprehensive endpoints—IVIS imaging, survival tracking, histology (H&E/IHC), qPCR, flow cytometry, and more.
Proven Success in IND-Enabling Projects
With 200+ oncology studies completed and multiple IND applications supported, our CRO platform combines validated workflows with expert guidance to accelerate your drug development with confidence.
Related Resources
Events & Webinars
Special Event MaRS Center 2026
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Promotional Campaign
Shared-Access 300: Fast-Track KO Program
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Blogs & Insights
Is INHBE Only Half of the Activin Story?
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Resource Vault
HUGO-GT™ Models：Efficacy Data & Core Advantages for Small Nucleic Acid Drug Therapeutics
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Partner with Cyagen to advance your preclinical studies. Share your project goals with us and receive customized support.
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