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Humanized Immune System Mouse Models
Cyagen’s huPBMC, huHSC, and huBLT models deliver >80% CD45+ engraftment with GLP-compliant protocols and 12-week rapid generation. Achieve translational accuracy in preclinical studies for oncology, autoimmune, and infectious disease research—minimize variability and meet IND milestones faster.
CRS Risk Profiling
Predict cytokine release syndrome using HLA-matched donor cells and functional T-cell assays.
High Humanization Metrics
55% hCD3+ engraftment validated via flow cytometry, ensuring human-like immune responses.
Dual-Engraftment Flexibility
PBMC/HSC co-optimized platform enables rapid T-cell studies or sustained immune reconstitution.
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Overview
Translational-Grade Immune Mice: Your Bridge from CAR-T Safety Data to Clinic
Cyagen’s NKG platform enables dual PBMC/HSC engraftment in immunodeficient mice, achieving >55% hCD3+ humanization to model tumor immunology, autoimmune responses, and infectious disease mechanisms with clinical fidelity. Accelerate therapeutic development and CRS risk assessment in human-relevant systems.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
Oncology CRO Platform
End-to-end preclinical oncology support from models to IND data
Cell Immunotherapy CRO Platform
CAR-T/NK development with custom vectors, models, and in vivo validation
Rodent Breeding
Scalable colony expansion with full genotyping support
Cryopreservation & Recovery
Preserve and revive rodent strains on demand
Rodent Phenotyping
Full-spectrum analysis for rodents model
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Catalog NumberNameBase StrainResearch ApplicationAction
C001543huHSC-NKG-ProFNKGTumor Immunology Research: Development of drugs such as immune checkpoint inhibitors, tumor vaccines, allogeneic cell therapies, and oncolytic viruses, as well as investigations into mechanisms that reverse T cell exhaustion, antibody-dependent cellular cytotoxicity (ADCC), and tumor-specific immunity；Autoimmune Disease Research: Evaluation of the mechanisms underlying the onset of autoimmune diseases and the exploration of therapeutic strategies；Drug Metabolism and Toxicity Research: Assessment of candidate compounds' pharmacokinetic properties and toxic effects in vivo
C001328huHSC-NKGNKGLong-term research in the fields of tumor immunity, hematopoiesis, and gene therapy for hematologic and infectious diseases.
C001329huPBMC-NKGNKGShort-term studies requiring mature T cells in the fields of tumor immunity, Hematopoiesis, and gene therapy for hematologic and infectious diseases.
C001526huHSC-NKG-hIL15NKGResearch on the human immune system, haematopoietic system；Human-derived cell line xenograft (CDX) and patient-derived xenograft (PDX)；NK cell development mechanism studies, NK cell-related tumor immunotherapy development, and antibody-dependent NK cell-mediated toxicity (ADCC) studies
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FAQs
Frequently Asked Questions (FAQs)
Do you offer HLA-typed or gene-edited custom models?
Yes. Cyagen provides:

HLA-transgenic models (e.g., HLA-A2) for antigen-specific T-cell responses.
HUGO-GT™ mice with full human gene replacements (e.g., hTCF4 for repeat expansion diseases).
Immune checkpoint humanized models (e.g., hOX40, hPD-1) for IO therapeutic screening.
What are timelines and success rates for model generation?
PBMC models: Ready in 6 weeks with >80% engraftment success.
HSC models: Full reconstitution in 12–16 weeks with >75% success.
Our TurboKnockout® platform accelerates gene-edited model production by 4–6 months vs. traditional ES cell methods.
How do your models improve lymphoid architecture and myeloid development?
Cyagen’s huBLT models (bone marrow-liver-thymus engraftment) enhance lymph node organogenesis and antigen presentation. NKG mice express human cytokines (e.g., GM-CSF/IL-3) to support myeloid cell development, overcoming limitations in legacy NSG/NOG models.
Can your models predict CRS for cell therapies like CAR-T?
Yes. Using HLA-matched donor cells and functional T-cell assays (e.g., PD-1/CTLA-4 expression profiling), our models replicate human-specific cytokine cascades (e.g., IL-6/IL-1β surges), enabling predictive CRS risk assessment for IND submissions.
What QC metrics validate human-like immune responses in your models?
We guarantee >55% hCD3+ humanization via flow cytometry, ensuring clinical relevance for T-cell-dependent responses. HLA-matched donor cells reduce xenogeneic rejection, and our NKG platform is validated for myeloid/lymphoid lineage development, critical for autoimmune and infectious disease studies.
How does your dual-engraftment (PBMC/HSC) platform resolve trade-offs between rapid T-cell studies and long-term immune reconstitution?
Cyagen’s NKG immunodeficient mice support dual-engraftment—PBMC transplants enable rapid T-cell studies (2–3 weeks post-transplant) for CAR-T/ICI efficacy, while HSC engraftment achieves stable immune reconstitution (>45 weeks) for chronic disease modeling. This eliminates the need for separate models, streamlining preclinical workflows.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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