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Autoimmune Disease Models
Reduce technical risk with rigorously validated, publication-ready models (e.g., BSA+CCL4+LPS-induced IgA Nephropathy) and TurboKnockout®-engineered efficiency (60% faster gene editing). Ethically optimized designs align with 3R principles to streamline IND-enabling studies.
Clinical Predictability
Achieve 85% translational concordance with IND-enabling histopathology and cytokine data.
Target Validation
Uncover novel pathways using gene-engineered models (e.g., TLR2 KO) with tissue-specific promoters.
Precision Drug Profiling
Test candidate efficacy and immune safety in models pre-validated with human biomarkers (e.g., Th17/Treg ratios).
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Overview
Customizable Autoimmune Models: Compliant, Fast, Publication-Ready
Cyagen accelerates therapeutic discovery with gene-edited models (CIA, EAE, TLR/DBA), offering end-to-end support from design to delivery. Meet deadlines with 12-week TurboKnockout® timelines and pre-validated datasets for peer review or FDA submissions.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
Autoimmune & Inflammation CRO Platform
Advancing autoimmune drug discovery with models and efficacy data.
Oncology CRO Platform
End-to-end preclinical oncology support from models to IND data
Rodent Breeding
Scalable colony expansion with full genotyping support
Rodent Phenotyping
Full-spectrum analysis for rodents model
Cryopreservation & Recovery
Preserve and revive rodent strains on demand
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Model Selection Made Simple
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Catalog NumberNameBase StrainResearch ApplicationAction
C001776Cfh KOC57BL/6JCyaResearch on the regulatory mechanisms of the complement system;Atypical hemolytic uremic syndrome (aHUS) pathogenesis research and treatment drug assessment;Age-related macular degeneration (AMD) pathological model construction and intervention strategy development;Mechanistic exploration of complement overactivation in autoimmune diseases;Pathological research of kidney diseases associated with complement deposition (e.g., C3 glomerulopathy)
I001220B6-hPCSK9/Apoe KOC57BL/6CyaDevelopment, screening, and preclinical evaluation of PCSK9-targeted drugs;Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
C001791B6-hIL1BC57BL/6NCyaIL1B-targeted drug screening, development, and evaluation;Research on the pathological mechanisms and therapeutic approaches of gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes (T2D), and other inflammatory and autoimmune diseases;Research on the pathological mechanisms and therapeutic approaches of cancers;Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases
C001787B6-hLAG3C57BL/6JCyaLAG3-targeted drug screening, development, and evaluation;Research on the pathological mechanisms and therapeutic approaches of malignant tumors such as melanoma, colorectal cancer, and non-small cell lung carcinoma;Research on the pathological mechanisms and therapeutic approaches of chronic infections including HIV infection, hepatitis B, and tuberculosis;Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases like rheumatoid arthritis and Hashimoto's thyroiditis
C001535BALB/c-Zap70*W163C (SKG)BALB/cAnCyaResearch on T cell signal transduction;Research on rheumatoid arthritis (RA);Research on ankylosing spondylitis (AS);Research on other autoimmune diseases
C001263Tlr2 KOC57BL/6JCyaHost responses to bacterial endotoxins such as septic shock
C001233Tlr3 KOC57BL/6NCyaStudies related to the toll-like receptor pathway of the innate immune response, among others
C001234Tlr4 KOC57BL/6NCyaInnate immune response studies;PAMP and DAMP studies;Respiratory syncytial virus research;Inflammatory response, anti-viral infection and tumor therapy studies
C001230Il10 KOC57BL/6NCyaResearch in areas including inflammatory bowel disease (IBD), such as Crohn’s disease (CD) and colitis, cancer, congenital and adaptive immune diseases, and many other inflammation or autoimmune research fields.
C001527BALB/c-Il10 KOBALB/cAnCyaResearch on inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and colitis;Research on cancer, congenital and adaptive immune disorders, and other inflammatory or autoimmune conditions
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FAQs
Frequently Asked Questions (FAQs)
Are histopathological benchmarks included for clinical correlation?
Yes. Synovial inflammation scoring (H&E, Safranin O) and CNS demyelination indices (LFB/PAS) adhere to MIATA/ARRIVE guidelines, with pathologist-verified severity scales.
How are comorbidities (e.g., IBD dysbiosis) controlled?
Defined microbiota diets, cohousing, and antibiotic regimens isolate autoimmune mechanisms. 16s rRNA sequencing and lamina propria profiling distinguish primary pathology.
Do models replicate human immune responses for IND submissions?
Yes. HLA-transgenic models (HLA-DR3/4) and PBMC/human cytokine systems mimic human responses, pre-validated for MHC-II–peptide interactions and checkpoint inhibitor studies.
How do you ensure long-term model stability (e.g., NOD mice)?
≥10 generations of backcrossing, SNP monitoring, and cryopreservation minimize drift. Phenotypic checkpoints (insulitis scoring, autoantibody titers) ensure consistency.
Can you engineer tissue-specific gene edits (e.g., Tlr2 KO in T cells)?
Yes. Cre-loxP inducible systems and tissue-specific promoters (CD4, CD11c) enable precise targeting. Dual-gene edits (Il23r/Stat3 KO) dissect polygenic interactions.
How do your models replicate human autoimmune biomarkers (e.g., lupus)?
Validated using disease-specific biomarkers: Th17/Treg ratios (flow cytometry), serum autoantibodies (anti-dsDNA), and cytokine panels (IL-17, TNF-α). Immune profiling (CD4+ T cells, B220+ B cells) aligns with human pathologies like SLE or RA.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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