Autoimmune Disease Models
Reduce technical risk with rigorously validated, publication-ready models (e.g., BSA+CCL4+LPS-induced IgA Nephropathy) and TurboKnockout™-engineered efficiency (60% faster gene editing). Ethically optimized designs align with 3R principles to streamline IND-enabling studies.
Clinical Predictability
Achieve 85% translational concordance with IND-enabling histopathology and cytokine data.
Target Validation
Uncover novel pathways using gene-engineered models (e.g., TLR2 KO) with tissue-specific promoters.
Precision Drug Profiling
Test candidate efficacy and immune safety in models pre-validated with human biomarkers (e.g., Th17/Treg ratios).
Overview
Product
FAQs
Customizable Autoimmune Models: Compliant, Fast, Publication-Ready
Cyagen supports autoimmune disease research and therapeutic development with established induced mouse models, including collagen-induced arthritis (CIA) models for rheumatoid arthritis research and experimental autoimmune encephalomyelitis (EAE) models for multiple sclerosis studies. We also provide genetically engineered mouse models for investigating immune pathways such as Toll-like receptor signaling. Our end-to-end services cover model design, generation, disease induction, phenotyping, efficacy evaluation, and study-ready data delivery.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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Citation Database
Molecular Therapy: Methods & Clinical Development, March, 2025
Intracranial AAV administration dose-dependently recruits B cells to inhibit the AAV redosing
【Other】
Gut, February, 2025
E-twenty-six-specific sequence variant 5 (ETV5) facilitates hepatocellular carcinoma progression and metastasis through enhancing polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC)-mediated immunosuppression
【Other】
Cell Death & Disease, February, 2025
Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage
【Other】
Molecular Therapy, February, 2025
Single-cell data-driven design of armed oncolytic virus to boost cooperative innate-adaptive immunity against cancer
【Other】
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