Autoimmune Disease Models

Reduce technical risk with rigorously validated, publication-ready models (e.g., BSA+CCL4+LPS-induced IgA Nephropathy) and TurboKnockout®-engineered efficiency (60% faster gene editing). Ethically optimized designs align with 3R principles to streamline IND-enabling studies.

Clinical Predictability

Achieve 85% translational concordance with IND-enabling histopathology and cytokine data.

Target Validation

Uncover novel pathways using gene-engineered models (e.g., TLR2 KO) with tissue-specific promoters.

Precision Drug Profiling

Test candidate efficacy and immune safety in models pre-validated with human biomarkers (e.g., Th17/Treg ratios).

Overview

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FAQs

Overview

Customizable Autoimmune Models: Compliant, Fast, Publication-Ready

Cyagen accelerates therapeutic discovery with gene-edited models (CIA, EAE, TLR/DBA), offering end-to-end support from design to delivery. Meet deadlines with 12-week TurboKnockout® timelines and pre-validated datasets for peer review or FDA submissions.

Explore Ready-to-Use Mouse Models

Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.

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Rodent Breeding

Scalable colony expansion with full genotyping support

Rodent Phenotyping

Full-spectrum analysis for rodents model

Cryopreservation & Recovery

Preserve and revive rodent strains on demand

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Model Selection Made Simple

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Base Strain

Catalog Number

Catalog Number	Name	Base Strain	Research Application
C001776	Cfh KO	C57BL/6JCya	Research on the regulatory mechanisms of the complement system；Atypical hemolytic uremic syndrome (aHUS) pathogenesis research and treatment drug assessment；Age-related macular degeneration (AMD) pathological model construction and intervention strategy development；Mechanistic exploration of complement overactivation in autoimmune diseases；Pathological research of kidney diseases associated with complement deposition (e.g., C3 glomerulopathy)
I001220	B6-hPCSK9/Apoe KO	C57BL/6Cya	Development, screening, and preclinical evaluation of PCSK9-targeted drugs；Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
C001791	B6-hIL1B	C57BL/6NCya	IL1B-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes (T2D), and other inflammatory and autoimmune diseases；Research on the pathological mechanisms and therapeutic approaches of cancers；Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases
C001787	B6-hLAG3	C57BL/6JCya	LAG3-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of malignant tumors such as melanoma, colorectal cancer, and non-small cell lung carcinoma；Research on the pathological mechanisms and therapeutic approaches of chronic infections including HIV infection, hepatitis B, and tuberculosis；Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases like rheumatoid arthritis and Hashimoto's thyroiditis
C001535	BALB/c-Zap70*W163C (SKG)	BALB/cAnCya	Research on T cell signal transduction；Research on rheumatoid arthritis (RA)；Research on ankylosing spondylitis (AS)；Research on other autoimmune diseases
C001263	Tlr2 KO	C57BL/6JCya	Host responses to bacterial endotoxins such as septic shock
C001233	Tlr3 KO	C57BL/6NCya	Studies related to the toll-like receptor pathway of the innate immune response, among others
C001234	Tlr4 KO	C57BL/6NCya	Innate immune response studies；PAMP and DAMP studies；Respiratory syncytial virus research；Inflammatory response, anti-viral infection and tumor therapy studies
C001230	Il10 KO	C57BL/6NCya	Research in areas including inflammatory bowel disease (IBD), such as Crohn’s disease (CD) and colitis, cancer, congenital and adaptive immune diseases, and many other inflammation or autoimmune research fields.
C001527	BALB/c-Il10 KO	BALB/cAnCya	Research on inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and colitis；Research on cancer, congenital and adaptive immune disorders, and other inflammatory or autoimmune conditions

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What Customers Say About Cyagen

Violet Shimmer

Stanford University

The service provided to us by Cyagen is now in press at Nature as an article.

Scarlett Rouge

Seattle Children’s Hospital

We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.

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