Are histopathological benchmarks included for clinical correlation?

Yes. Synovial inflammation scoring (H&E, Safranin O) and CNS demyelination indices (LFB/PAS) adhere to MIATA/ARRIVE guidelines, with pathologist-verified severity scales.

How are comorbidities (e.g., IBD dysbiosis) controlled?

Defined microbiota diets, cohousing, and antibiotic regimens isolate autoimmune mechanisms. 16s rRNA sequencing and lamina propria profiling distinguish primary pathology.

Do models replicate human immune responses for IND submissions?

Yes. HLA-transgenic models (HLA-DR3/4) and PBMC/human cytokine systems mimic human responses, pre-validated for MHC-II–peptide interactions and checkpoint inhibitor studies.

How do you ensure long-term model stability (e.g., NOD mice)?

≥10 generations of backcrossing, SNP monitoring, and cryopreservation minimize drift. Phenotypic checkpoints (insulitis scoring, autoantibody titers) ensure consistency.

Can you engineer tissue-specific gene edits (e.g., Tlr2 KO in T cells)?

Yes. Cre-loxP inducible systems and tissue-specific promoters (CD4, CD11c) enable precise targeting. Dual-gene edits (Il23r/Stat3 KO) dissect polygenic interactions.

How do your models replicate human autoimmune biomarkers (e.g., lupus)?

Validated using disease-specific biomarkers: Th17/Treg ratios (flow cytometry), serum autoantibodies (anti-dsDNA), and cytokine panels (IL-17, TNF-α). Immune profiling (CD4+ T cells, B220+ B cells) aligns with human pathologies like SLE or RA.

Custom Autoimmune Disease Models for High-Quality Research

Autoimmune Disease Models

Reduce technical risk with rigorously validated, publication-ready models (e.g., BSA+CCL4+LPS-induced IgA Nephropathy) and TurboKnockout®-engineered efficiency (60% faster gene editing). Ethically optimized designs align with 3R principles to streamline IND-enabling studies.

Clinical Predictability

Achieve 85% translational concordance with IND-enabling histopathology and cytokine data.

Target Validation

Uncover novel pathways using gene-engineered models (e.g., TLR2 KO) with tissue-specific promoters.

Precision Drug Profiling

Test candidate efficacy and immune safety in models pre-validated with human biomarkers (e.g., Th17/Treg ratios).

Overview

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FAQs

Overview

Customizable Autoimmune Models: Compliant, Fast, Publication-Ready

Cyagen accelerates therapeutic discovery with gene-edited models (CIA, EAE, TLR/DBA), offering end-to-end support from design to delivery. Meet deadlines with 12-week TurboKnockout® timelines and pre-validated datasets for peer review or FDA submissions.

Explore Ready-to-Use Mouse Models

Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.

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End-to-end preclinical oncology support from models to IND data

Rodent Breeding

Scalable colony expansion with full genotyping support

Rodent Phenotyping

Full-spectrum analysis for rodents model

Cryopreservation & Recovery

Preserve and revive rodent strains on demand

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Model Selection Made Simple

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Base Strain

Catalog Number

Catalog Number	Name	Base Strain	Research Application
C001891	A129 (Ifnar1 KO)	129S2/SvPasCya	Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV； Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling.
C001893	AG129	129S2/SvPasCya	Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV; Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling.
C001603	B6-hTL1A (TNFSF15)	C57BL/6JCya	T cell differentiation and survival studies; Immune response regulation research; Pathogenesis of autoimmune diseases studies; TL1A-targeted drug screening, development, and evaluation.
C001701	B6-hFcRn (Extra)	C57BL/6NCya	In vivo transport, maintenance, and metabolism studies of IgG; Development and screening of IgG antibody drug candidates; Pharmacology, efficacy, and pharmacokinetics of IgG antibody drugs; Evaluation of Fc-based immunotherapy.
C001917	B6-hIL31RA	C57BL/6NCya	Screening, development, and pre-clinical evaluation of IL31RA-targeted drugs; Research on the pathogenic mechanisms and relevant treatment methods of inflammatory and pruritic diseases such as atopic dermatitis, prurigo nodularis, allergic asthma, and certain cutaneous T-cell lymphomas.
C001913	B6-huTNFR2 (huTNFRSF1B)	C57BL/6NCya	Screening, development, and pre-clinical evaluation of TNFRSF1B-targeted drugs; Research on autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease); Research on various malignant tumors (such as breast cancer, cervical cancer, and colorectal cancer); Research on neurodegenerative diseases such as Alzheimer's disease and schizophrenia.
C001619	B6-huIL12B	C57BL/6NCya	Screening, development, and preclinical efficacy evaluation of IL12B-targeted drugs; Study of pathological mechanisms and therapeutic methods for immune-related diseases and cancer.
C001812	B6-huIL4/huIL13/huTSLP	C57BL/6NCya	Screening, development, and pre-clinical evaluation of IL-4/IL13/TSLP-targeted drugs; Research on allergic diseases, inflammation, and autoimmune diseases; Research on immune regulation, Th2 response, parasitic infections, and tumor immunity.
C001617	B6-hPCSK9	C57BL/6NCya	Development and screening of PCSK9-targeted therapies； Preclinical pharmacological and efficacy evaluation of PCSK9-targeted therapies； Research on metabolic diseases such as hypercholesterolemia, atherosclerosis, and coronary heart disease； Research on neurodegenerative diseases such as stroke and Alzheimer's disease.
C001936	B6-huOX40/huOX40L	C57BL/6NCya	Screening, development, and pre-clinical evaluation of TNFSF4/TNFRSF4-targeted drugs; Research on the pathological mechanisms and treatment methods of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA); Research on tumor immunology; Research on immunodeficiency type 16.

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FAQs

Citation Database

Molecular Therapy: Methods & Clinical Development, March, 2025

Intracranial AAV administration dose-dependently recruits B cells to inhibit the AAV redosing

【Other】

Gut, February, 2025

E-twenty-six-specific sequence variant 5 (ETV5) facilitates hepatocellular carcinoma progression and metastasis through enhancing polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC)-mediated immunosuppression

【Other】

Cell Death & Disease, February, 2025

Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage

【Other】

Molecular Therapy, February, 2025

Single-cell data-driven design of armed oncolytic virus to boost cooperative innate-adaptive immunity against cancer

【Other】

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