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Metabolic Disease Models

Accelerate metabolic and cardiometabolic research with validated, in-stock mouse models, including humanized, point mutation, and diet-induced obesity (DIO) models for drug discovery and preclinical development.
High-Quality Phenotype Analysis
Detailed evaluation services for metabolic disorders. Ensures robust data for research outcomes.
Genetic Modification Options
Tailored gene-edited mouse models. ​Enhances accuracy in studying metabolic disorders.​
Diverse Metabolic Disease Models
Access a wide range of gene-edited mouse models tailored for metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis.
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Overview

Validated Mouse Models for Metabolic and Cardiometabolic Research

Cyagen provides a comprehensive portfolio of ready-to-use mouse models for studying metabolic and cardiometabolic diseases, including obesity, diabetes, dyslipidemia, cardiovascular disease, and related metabolic disorders.

Our portfolio includes humanized mouse models, disease-associated point mutation models, conventional genetically engineered models, and diet-induced obesity (DIO) models. These models support a broad range of preclinical applications, from disease mechanism and target validation to pharmacology, efficacy evaluation, and therapeutic development.

With diverse model strategies designed to capture distinct aspects of human metabolic disease biology, researchers can select the model best suited to their target, pathway, therapeutic modality, and study objective.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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Custom genomic edits with full validation and transgenic support
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Preserve and revive rodent strains on demand
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Model Selection Made Simple
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Catalog NumberNameBase StrainResearch ApplicationAction
C001507Apoe-KO(6J)C57BL/6JCyaCardiovascular disease research: Hypercholesterolemia, hyperlipidemia, atherosclerosis, etc.; Body metabolism mechanism research: Fat and cholesterol metabolism; Neurodegenerative disease research: Alzheimer's disease.
C001849Alpl-KOC57BL/6JCyaResearch on hypophosphatasia (HPP); Research on osteoporosis; Research on osteosarcoma (OS).
C001703Agxt-KOC57BL/6NCyaStudies of glyoxylate metabolism regulation; Primary Hyperoxaluria pathogenesis and therapeutic drug evaluation.
C001889Acute-PKD(inducible)C57BL/6N;6JCyaResearch on renal tubular calcium homeostasis and mechanotransduction; Research on renal tubular structure, function, and signal transduction; Research on autosomal dominant polycystic kidney disease (ADPKD); Research on other renal diseases.
C001590Abcb4-KO(FVB)FVB/NJCyaStudy of Multidrug Resistance Protein 3 (MDR3) function; Mechanistic studies of Progressive Familial Intrahepatic Cholestasis Type 3 (PFIC3); Drug development, screening, and preclinical efficacy evaluation for PFIC3 treatment.
C001267Atp7b-KOC57BL/6NCyaCopper Metabolism Research; Wilson’s Disease Research; Acute Liver Failure Research; Steatohepatitis Research; Other Research Related to Copper Metabolism Disorders.
C001522B6-hLPA (CKI) /Alb-creC57BL/6NCyaResearch on atherosclerosis, hyperlipidemia, thrombotic cardiovascular diseases, etc; Preclinical evaluation of human LPA-targeted drugs.
C001521B6-hLPA (CKI)C57BL/6NCyaResearch on atherosclerosis, hyperlipidemia, thrombotic cardiovascular diseases, etc.; Preclinical evaluation of human LPA-targeted drugs.
C001642B6-hKHKC57BL/6NCyaScreening, development, and evaluation of KHK-targeted drugs; Research on the pathological mechanisms and treatment methods of metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), insulin resistance, obesity, etc., as well as cancer.
C001600B6-hINHBE/obC57BL/6NCya;C57BL/6JCyaResearch on the obesity and type II diabetes; Research on the metabolic diseases associated with improper fat distribution and storage; Development of human INHBE-targeted therapies.
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Citation Resources
Nature Genetics
2026-07-07
Metabolically and epigenetically reprogrammed splenic TRNP1hiCD8+ T cells exacerbate liver fibrosis
Read More
The Journal of Experimental Medicine
2026-07-05
Interferon-λ drives renal fibrosis by coordinating epithelial–fibroblast crosstalk
Read More
iScience
2026-06-21
Genetic ablation of Sfxn5 induces mitochondrial dysfunction and precipitates lethal metabolic crisis in mice
Read More
FAQs

Frequently Asked Questions (FAQs)

When should I consider a humanized mouse model for metabolic disease research?

Humanized mouse models may be particularly useful when species differences in a therapeutic target could affect target engagement, pharmacological activity, or translational relevance. They are especially valuable for sequence-dependent modalities, including siRNA, ASO, and other oligonucleotide-based therapeutics, where the human target sequence may be required for meaningful in vivo evaluation.

How do I choose the right mouse model for my metabolic disease study?

Model selection depends on the disease mechanism, therapeutic target, pathway of interest, therapeutic modality, and study endpoints. Genetic models may be better suited for investigating specific disease-associated genes or mutations, while DIO models are commonly used to study obesity, insulin resistance, and related metabolic phenotypes. Cyagen's PhD-level scientific team can also help identify the most appropriate genetic, humanized, point mutation, or diet-induced model based on your research objectives and study design.

Are ready-to-use metabolic disease mouse models suitable for preclinical efficacy studies?

Yes. Many of Cyagen’s metabolic disease mouse models are ready to use and supported by existing validation data, allowing researchers to begin studies without starting model development from scratch. This can shorten study initiation timelines and provide greater predictability for project planning, enabling earlier progression into pharmacology and efficacy evaluation.

Does Cyagen offer customization options for specific metabolic pathways or receptor modifications relevant to drug targets?

Yes. Cyagen provides customized model development for specific metabolic pathways, receptors, and drug targets. This is particularly valuable for oligonucleotide-based therapeutics, where efficacy often depends on precise target-sequence matching. Our experienced model development team can rapidly generate humanized models tailored to the relevant target sequence, while our ready-to-use portfolio already includes humanized models covering a broad range of therapeutically relevant targets.

What endpoints can be evaluated in metabolic disease mouse studies?

Common endpoints include body weight, food intake, blood glucose, glucose tolerance, insulin sensitivity, serum lipids, circulating biomarkers, body composition, tissue histology, and molecular or biochemical readouts. The appropriate endpoints depend on the disease model and the therapeutic mechanism being investigated.
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