Turboknockout® Gene Editing
Turboknockout® gene targeting is a next-generation ESC-based technology that delivers precise, efficient genetic modifications. With its 100% germline transmission guarantee and fast turnaround time, Turboknockout® accelerates complex model generation while avoiding patent disputes, making it the preferred choice for researchers in drug development and biomedical studies.
Large & Complex Knockins
Supports knockins up to 300 kb for complex genetic modifications.
Rapid Model Generation
Produces gene-edited mouse models in as little as 6-8 months.
Freedom to Operate
Patent dispute-free, enhancing drug development efficiency.
Technology
Applications
FAQs
How TurboKnockout® Works
TurboKnockout® technology incorporates two key innovations:
super-competent ES cells, which generate 100% ESC-derived founders
without the need for chimeric screening, and a self-deleting Neo
cassette, which removes itself during the targeting process, eliminating
the need for Flp breeding and reducing project timelines by 4-6 months.
TurboKnockout® vs. Other Gene Editing Methods
Leverage our cutting-edge Targeted Gene Editing technology for rapid and
precise knockout rat generation, tailored to meet stringent
research specifications.
| Feature | TurboKnockout® | Targeted Gene Editing | Traditional Targeting |
|---|---|---|---|
| Turnaround Time | 6-8 months | 5-7 months | 10-14 months |
| Knockin Size | Up to 300 kb | ≤15 kb | Up to 300 kb |
| Patent Risks | None | High | None |
| Germline Transmission | Guaranteed (100%) | Variable | Requires Screening |
Step-by-Step Workflow
Step1: Homologous recombination in
TurboKnockout®-enhanced ESCs.
Step2: Targeting construct with
self-deleting cassette inserted.
Step3: Direct breeding to Cre mice for
conditional models.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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