Ophthalmic CRO Services
Cyagen offers comprehensive ophthalmic CRO solutions, from custom animal models to drug administration and validation, ensuring efficient and reliable results throughout preclinical research.
One-Stop Ophthalmology CRO Solutions
At Cyagen, we leverage over 20+ experience in gene therapy and advanced technical
infrastructure to deliver end-to-end ophthalmology research solutions. Our platform supports ocular drug
development with a wide range of customized disease models, advanced in vivo drug administration, and
comprehensive phenotyping and molecular validation. With a proven track record of delivering over 500 CRO
projects and accelerating more than 20 IND applications, we ensure precise, efficient, and reliable results at
every stage of your research.
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Cyagen offers an extensive collection of ophthalmic disease models, spanning genetic, humanized,
and
inducible types. The map below provides a visual overview of our available models categorized by
disease area—helping you quickly identify the best-fit model for your study.
Ophthalmic
Disease Models
Disease Models
Inherited Retinal Degeneration
Retinitis Pigmentosa (RP)
HUGO-GT Models
- B6-hRho
- B6-hRHO-P23H
- B6-hRHO (Promoter)
- B6-hRHO (Promoter)-P23H
- B6-hNRL
Other Genetic Models
- Rho KO, Pde6b KO, RPGR KO
- Tub-KO, Rph2 KO, Nr2e3 KO
Inducible Models
- MNU-Induced RP
Leber Congenital Amaurosis (LCA)
HUGO-GT Models
- B6-hCEP290, B6-hCRB1
- B6-hCRX, B6-hGUCY2D
Other Genetic Models
- Rpe65 KO, Rpe65 R44X, RDH12 KO
Stargardt Disease
HUGO-GT Models
- B6-hABCA4, B6-hABCA4 c.5461-10T>C
Usher Syndrome Type 2
HUGO-GT Models
- B6-hUSH2A (E10-15), B6-hUSH2A c.2299 del G
Explore models
Macular Disorders
Wet Age-related Macular Degeneration (Wet AMD)
HUGO-GT Models
- B6-hVEGFA, B6-hANG2 (ANGPT2)
Other Genetic Models
- hVEGFA-TG
Inducible Models
- Laser-Induced CNV
Dry Age-related Macular Degeneration (dAMD)
HUGO-GT Models
- B6-hC3, B6-hC5
Inducible Models
- Sodium Iodate-Induced dAMD
- Blue Light-Induced dAMD
Explore models
Corneal Disorders
Corneal Dystrophy (CD)
HUGO-GT Models
- B6-hTGFBI, B6-hTCF4
- Dry Eye Syndrome
Inducible Models
- BAC/Benzalkonium Chloride-Induced
- Hyoscine (Scopolamine)-Induced
- OVX Female Mice-Induced
Corneal Neovascularization
Inducible Models
- NaOH-Induced Corneal Neovascularization
Glaucoma & Intraocular Tumors
Glaucoma
HUGO-GT Models
- B6-hANGPTL7
Inducible Models
- Ischemia–Reperfusion-Induced Glaucoma
- Magnetic Bead Occlusion-Induced Glaucoma
- NMDA-Induced Glaucoma
- Optic Nerve Crush Injury-Induced Glaucoma
Retinoblastoma
Inducible Models
- Y-79 Cells-Induced RB
Explore models
Retinal Vascular & Fibrotic Disorders
Optic Neuropathy & CRVO
Inducible Models
- Laser-Induced Traumatic Neuropathy
- Laser-Induced Central Retinal Vein Occlusion (CRVO)
Subretinal Fibrosis
Inducible Models
- Laser-Induced Subretinal Fibrosis
Explore models
Search Genetic & Humanized Models
Use the filters below to search by disease, gene, or model type. All listed
models are available for inquiry and can be customized based on your project needs.
Base Strain
Search for Models
| Catalog Number | Name | Base Strain | Research Application | Action |
|---|---|---|---|---|
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Explore Inducible and Surgical Models
In addition to genetic models, Cyagen provides a wide range of inducible and surgical models for
studying complex ocular conditions. These models are widely used in pharmacological research,
especially for evaluating intraocular drug delivery, retinal degeneration, and vascular
responses.
| Related Diseases | Modeling Method | Strain Background |
|---|---|---|
| Glaucoma | Ischemia-Reperfusion-Induced | Mouse |
| Glaucoma | Magnetic Bead Occlusion-Induced | Mouse & Rat |
| Glaucoma | N-Methyl-D-Aspartate (NMDA)-Induced | Mouse & Rat |
| Glaucoma | Optic Nerve Crush Injury | Mouse |
| Dry Eye Syndrome | Benzalkonium Chloride (BAC)-Induced | Mouse |
| Corneal Neovascularization | Sodium Hydroxide (NaOH)-Induced | Mouse & Rat |
| Wet AMD | Laser-Induced Choroidal Neovascularization (CNV) | Mouse & Rat |
| Dry AMD | Sodium Iodate-Induced | Mouse |
| Dry AMD | Blue Light-Induced | Mouse |
| Subretinal Fibrosis | Laser-Induced | Mouse & Rat |
| Retinitis Pigmentosa (RP) | N-Methyl-N-nitrosourea (MNU)-Induced | Mouse & Rat |
| Retinoblastoma | Y-79 Cells-Induced | Mouse |
| Traumatic Neuropathy | Laser-Induced | Mouse & Rat |
| Central Retinal Vein Occlusion (CRVO) | Laser-Induced | Mouse & Rat |
Can't Find Your Model?
If your desired model isn't listed, our experts are here to help!
Request a
Custom Animal Model
>>
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At Cyagen, we offer advanced in vivo drug delivery and phenotyping services
tailored for ophthalmic studies. From precise ocular injections to high-resolution imaging and
vision behavior analysis, our platform provides comprehensive capabilities to evaluate drug efficacy
and safety. Supported by expert personnel and cutting-edge instrumentation, we ensure consistent,
accurate, and reproducible preclinical results.
Custom Injection Methods
- Intracameral injection
- Intravitreal injection
- Subretinal injection
- Subconjunctival injection
- Retrobulbar injection
Our injection techniques ensure accurate localization and minimal variability, with an
overall success rate exceeding 90%.
Non-Invasive Imaging
- Fundus photography (FP)
- Fundus autofluorescence (GFP/mCherry) imaging
- Fundus fluorescein angiography (FFA)
- Optical Coherence Tomography (OCT)
- Laser photocoagulation
- Slit-lamp biomicroscopy
- Indirect ophthalmoscopy
- Intraocular pressure (IOP) measurement
- Flash electroretinogram (f-ERG)
- Flash visual evoked potentials (f-VEP)
- Corneal fluorescein staining
- Corneal confocal microscopy examination
Vision Behavioral Testing
- Visual optomotor response (OMR) test
- Visual water maze test
- Visual light/dark box test
- Visual reflex assessment
Need tailored injection methods or behavioral assays for your ocular
study?
Case Examples
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Verify treatment efficacy and mechanism of action through detailed tissue-level
analysis and molecular assays. Cyagen provides end-to-end solutions for ocular histopathology,
molecular profiling, and biomarker validation—supporting your IND filings with reliable,
publication-ready data.
Tissue Collection & Preparation
- Precise dissection of ocular tissues (including retina, RPE cells, cornea, iris, aqueous humor, lens, vitreous, optic nerve, choroid & sclera) in mice, rats, and/or rabbits
- Specialized handling to preserve tissue structure and biomarker integrity for PK/PD studies
Histological Analysis
- Paraffin sections and frozen sections
- Flat-mount preparation of ocular tissues, including cornea, retina, and RPE–choroid complex
- H&E staining, immunohistochemistry (IHC), and immunofluorescence (IF)
- Morphological evaluation and pathology scoring
Molecular Assays
- Western blotting for protein expression profiling
- qPCR/RT-PCR for gene expression analysis
- Droplet digital PCR (ddPCR) for ultra-sensitive absolute quantification
- ELISA for cytokine and secreted protein measurement
- Flow cytometry for multiparametric cell analysis and sorting
- Supports biomarker discovery and mechanism validation
Need support for molecular and histological validation?
Case Examples
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Our Unique Advantages
Extensive Library of Validated Ocular Models
Cyagen offers a wide range of ready-to-use and customizable mouse models—including genetic, humanized, and induced types—covering major ocular diseases such as glaucoma, AMD, DR, and RP.
Full-Spectrum Efficacy Evaluation Platform
Our platform integrates precise ocular drug delivery, in vivo imaging (OCT/ERG/FFA), behavioral testing, and molecular pathology to deliver comprehensive efficacy evaluation.
Trusted CRO Partner for Translational Research
With 500+ projects completed and over 20 IND filings supported, Cyagen delivers reliable, publication-ready data that accelerates preclinical ophthalmic drug development.
Related Resources
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