Humanized Target Gene Disease Models
Generate CDS-humanized mouse models by replacing endogenous coding sequences with human CDS regions, enabling more clinically relevant target validation and efficacy studies while accelerating preclinical research and therapeutic development.
Clinically Validated Systems
Streamline testing of oncology, immunotherapies, and hematologic drugs in pre-validated, humanized environments.
Accelerated Model Development
Achieve 50% faster model delivery through gene-based engineering, outpacing traditional methods.
Custom Human Gene Integration
Seamlessly replace animal genes with human sequences to replicate disease mechanisms with unmatched accuracy.
Overview
Product
FAQs
How Are Target Gene-Humanized Mouse Models Generated?
Target gene humanization uses precise genome-editing strategies to replace selected mouse coding sequences with their human counterparts while preserving appropriate genomic context. The replacement may involve a specific exon, multiple exons, or the complete coding region, depending on the target, protein structure, and research requirements. This flexible approach allows the resulting model to express a human or partially humanized protein while maintaining endogenous expression patterns and tissue distribution.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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