BALB/c-Zap70*W163C (SKG)
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Basic Information
Model Name
BALB/c-Zap70*W163C (SKG)
Product ID
C001535
Gene Name
Background
BALB/cAnCya
Gene Alias
Srk; mur; mrtle; ZAP-70
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “BALB/c-Zap70*W163C (SKG) mice (Catalog C001535) were purchased from Cyagen.”
Strain Description
The BALB/c-Zap70*W163C (SKG) mouse (referred to as the SKG mouse) is an autoimmune disease research model constructed by Cyagen through gene editing technology to introduce the W163C mutation into the Zap70 gene of BALB/c mice. The phenotype of this model is similar to that of the classic SKG mouse. Under SPF conditions, upon triggering innate immune activation (such as β-glucan induction), it can present a variety of autoimmune disease phenotypes. Therefore, this mouse can be used for research on autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis-like skin inflammation, RA-associated interstitial lung disease (RA-ILD), and Crohn’s disease-like ileitis, as well as T cell signal transduction.
Application Area
Research on T cell signal transduction
Research on rheumatoid arthritis (RA)
Research on ankylosing spondylitis (AS)
Research on other autoimmune diseases
Validation Data