H11-Alb-hLPA
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Genotype
Sex
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Basic Information
Model Name
H11-Alb-hLPA
Product ID
C001542
Gene Name
Background
C57BL/6NCya
Gene Alias
LP; AK38; APOA
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
--
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “H11-Alb-hLPA mice (Catalog C001542) were purchased from Cyagen.”
Strain Description
The H11-Alb-hLPA mouse is a humanized model where the human LPA protein coding sequence (CDS) is integrated into the mouse H11 safe harbor locus. In this model, the human LPA gene is specifically expressed in the liver under the control of the mouse Alb promoter. It can be used to study the pathogenic mechanisms of the LPA gene in hyperlipidemia and related cardiovascular diseases, as well as to evaluate targeted drug development. Additionally, Cyagen has developed a conditionally inducible LPA humanization model (catalog number: C001521) using the CAG promoter. When crossed with Alb-Cre mice (liver-specific Cre mice), the resulting LPA-humanized mice (catalog number: C001522) exhibit significantly higher LPA protein levels compared to the H11-Alb-hLPA mice. Therefore, researchers please choose the appropriate mouse strain based on their specific requirements for LPA protein expression levels and genetic characteristics.
Application Area
Research on atherosclerosis, hyperlipidemia, thrombotic cardiovascular diseases, etc.
Preclinical evaluation of human LPA-targeted drugs
Validation Data