B6-hPCSK9 (CDS)
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hPCSK9 (CDS)
Product ID
C001593
Gene Name
Background
C57BL/6NCya
Gene Alias
FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hPCSK9 (CDS) mice (Catalog C001593) were purchased from Cyagen.”
Strain Description
B6-hPCSK9 (CDS) mice are generated by integrating the human PCSK9 protein coding sequence (CDS) and 3' untranslated region (UTR) into the mouse Pcsk9 gene locus using gene editing techniques, resulting in a model expressing human PCSK9 protein while disrupting the expression of the mouse endogenous Pcsk9 gene. These mice can be used to study various metabolic diseases, neurodegenerative diseases, tumor development, and autoimmune diseases, as well as for the development, screening, and preclinical pharmacological evaluation of PCSK9-targeted drugs. Compared to the similar B6-hPCSK9 mice (PCSK9 genomic humanized model, Catalog Number: C001617), B6-hPCSK9 (CDS) mice have higher levels of human PCSK9 protein expression in serum, while LDLR expression is closer to the normal endogenous levels in mice.
Application Area
Development and screening of PCSK9-targeted therapies
Preclinical pharmacological and efficacy evaluation of PCSK9-targeted therapies
Research on metabolic diseases such as hypercholesterolemia, atherosclerosis, and coronary heart disease
Research on neurodegenerative diseases such as stroke and Alzheimer's disease
Validation Data