B6-hSNCA (3'UTR)
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hSNCA (3'UTR)
Product ID
C001698
Gene Name
Background
C57BL/6NCya
Gene Alias
PD1; NACP; PARK1; PARK4
Classification
Full-Gene Humanized Models,Neurological Disease Models
NCBI ID
Phenotype
Chromosome
4
Document
Note: When using this mouse strain in a publication, please cite “B6-hSNCA (3'UTR) mice (Catalog C001698) were purchased from Cyagen.”
Strain Description
The B6-hSNCA (3'UTR) mouse is a humanized model constructed by replacing the mouse Snca gene in situ with the human SNCA gene, in which the sequences from ATG start codon to ~0.5 kb downstream of 3'UTR of the endogenous mouse Snca gene will be replaced with the sequences from ATG start codon to ~0.5 kb downstream of 3'UTR of the human SNCA gene. The homozygous B6-hSNCA (3'UTR) mice are viable and fertile and can be used for studies on Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA), and pathogenesis of neurodegenerative diseases, as well as for SNCA-targeted drug development.
Application Area
Parkinson's disease (PD) pathogenic mechanism research
Parkinson's disease (PD) therapeutic drug development and efficacy verification
Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) study
Validation Data