NKG-hSIRPα
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Basic Information
Model Name
NKG-hSIRPα
Product ID
C001707
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “NKG-hSIRPα mice (Catalog C001707) were purchased from Cyagen.”
Strain Description
The NKG-hSIRPα mouse is a humanized model constructed by replacing the exon 2 coding region plus partial intron 2 of the mouse Sirpa gene in situ with the "Human SIRPA CDS-3'UTR of Mouse Sirpa-WPRE-BGH pA" cassette. The homozygous NKG-hSIRPα mice are viable and fertile. Compared with NKG mice, NKG-hSIRPα mice further inhibit the phagocytosis of transplanted tumors by host macrophages through enhancing the function of the CD47-SIRPα signaling pathway, thus accelerating tumor growth. This model provides a crucial experimental platform for studying the ability of CAR-M therapy to overcome the immunosuppressive microenvironment, as well as for developing anti-tumor drugs targeting the CD47/SIRPα pathway.
Application Area
SIRPA-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of tumors that evade immunity by relying on the CD47-SIRPα pathway
Cell-derived xenograft (CDX) and patient-derived xenograft (PDX)
Validation Data