B6-hCD19
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Strain Description
B6-hCD19 mice are a humanized model generated by replacing the mouse endogenous Cd19 gene sequence from the ATG start codon to part of intron 4 with the corresponding human CD19 gene sequence using gene editing technology. This model is applicable for studying B cell development and function, as well as therapeutic research on autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and B cell malignancies. It is an ideal research platform for preclinical efficacy evaluation of anti-human CD19 CAR-T cell therapy, and the development of bispecific antibodies and combination therapies.
Application Area
Research on B cell development and function
Mechanism and therapeutic research on autoimmune diseases (e.g., systemic lupus erythematosus, SLE, rheumatoid arthritis, RA) and B cell malignancies, including preclinical efficacy evaluation of anti-human CD19 CAR-T cell therapy, development of bispecific antibodies, and combination therapies
Preclinical research on the development, screening, and pharmacodynamic evaluation of CD19-targeted therapeutic agents
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