B6-hCIDEB
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCIDEB
Product ID
C001803
Gene Name
Background
C57BL/6JCya
Gene Alias
--
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
14
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Note: When using this mouse strain in a publication, please cite “B6-hCIDEB mice (Catalog C001803) were purchased from Cyagen.”
Strain Description
The B6-hCIDEB mouse is a humanized model, constructed by replacing the sequences from exon 1 to partial intron 2 of mouse Cideb with the Human CIDEB genomic region (exon 1 to exon 5)-rBG pA cassette. B6-hCIDEB mice can be used for research into the pathogenesis of various liver conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV). They are also useful for the screening, development, and safety evaluation of CIDEB-targeted drugs.
Application Area
CIDEB-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various liver conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV)
Research on cell apoptosis and hepatocellular injury
Research on metabolic syndrome, obesity, and other lipid metabolism-related diseases
Validation Data