Krt19-iCre Mouse
Product Name
Krt19-iCre Mouse
Product ID
I001201
Strain Name
C57BL/6JCya-Krt19em1(iCre)/Cya
Backgroud
C57BL/6JCya
Status
When using this mouse strain in a publication, please cite “Krt19-iCre Mouse (Catalog I001201) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Krt19
Gene Alias
K19, CK-19, EndoC, Krt1-19, Krt-1.19
NCBI ID
Chromosome
Chr 11 (Mouse)
MGI ID
Datasheet
Strain Description
The KRT19 (K19) gene encodes a type I intermediate filament protein (Keratin 19), expressed in various types of epithelial cells from the embryonic layer to adult cells. It is notably expressed in the lungs, oral cavity, bronchi, bronchioles, stomach, and small intestine, as well as in the ductal cells of the pancreas, kidneys, and liver. This protein is a member of the keratin family and plays a crucial role in maintaining the structural integrity of epithelial cells. Deletion of the Krt19 gene can lead to inducible skeletal muscle disease in mice. Additionally, Keratin 19 can be used as a biomarker for detecting tumor cells in various tissues. Depending on the type of cancer cells, regulating the expression of KRT19 can have different impacts on cell proliferation, survival, invasion, migration, and apoptosis [1].
The Krt19-iCre mouse model is constructed by knocking a high-recombination activity iCre element (codon-optimized Cre) into the endogenous Krt19 gene in mice. When Krt19-iCre mice are crossed with mice containing loxP sites, Cre recombinase-mediated recombination between loxP sites is expected to occur in KRT19-expressing epithelial cells in the offspring.
Reference
Saha SK, Choi HY, Kim BW, Dayem AA, Yang GM, Kim KS, Yin YF, Cho SG. KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties. Oncogene. 2017 Jan 19;36(3):332-349.
Strain Strategy
The ATG start codon was replaced with the Kozak-iCre-WPRE-BGH pA cassette.
Figure 1. Gene editing strategy of Krt19-iCre mice.
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