PKD (inducible)
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Strain Description
PKD (inducible) mice represent an inducible conditional Pkd1 knockout model generated by crossing Pkd1-floxed mice with kidney-specific, tamoxifen-inducible Cre mice (Cdh16-MerCreMer). Offspring were induced with tamoxifen during lactation to achieve targeted deletion of Pkd1 within renal tubular epithelial cells. Preliminary observations at three weeks post-induction reveal pronounced polycystic kidney disease phenotypes, including the emergence of renal cysts, a marked increase in kidney volume, and elevated serum blood urea nitrogen (BUN) levels. We are continuing to monitor this model longitudinally to capture later-stage phenotypes and delineate the overall trajectory of disease progression.
Application Area
Calcium Homeostasis and Mechanotransduction
Renal Tubular Biology
ADPKD Modeling
Broader Kidney Disease Research
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