C57BL/6NCya-Adamts9em1flox/Cya
Common Name:
Adamts9-flox
Product ID:
S-CKO-00208
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Adamts9-flox
Strain ID
CKOCMP-101401-Adamts9-B6N-VA
Gene Name
Product ID
S-CKO-00208
Gene Alias
1810011L16Rik; 8430403M15Rik; E030027K14Rik; Gsfund3; Mhdaund3; Mhdaund4; UND3; UND4
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Adamts9em1flox/Cya mice (Catalog S-CKO-00208) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000113438
NCBI RefSeq
NM_175314
Target Region
Exon 13~14
Size of Effective Region
~2.5 kb
Detailed Document
Overview of Gene Research
ADAMTS9, also known as A disintegrin and metalloprotease with thrombospondin type-1 motif, member 9, is a secreted extracellular metalloproteinase. It is involved in various biological processes, such as regulating skeletal muscle insulin sensitivity, primary cilia formation and function, and ovarian development. It may act through pathways like integrin β1 signaling in the context of insulin regulation [1,2,3].
In mouse models, skeletal muscle-specific knockout of Adamts9 led to improved insulin sensitivity. This indicates that ADAMTS9 can regulate insulin sensitivity and signaling in skeletal muscle, potentially through alterations of the integrin β1 signaling pathway and disruption of intracellular cytoskeletal organization [1]. In zebrafish, knockout of adamts9 resulted in abnormal ovarian development, with significantly fewer adult female mutants and abnormal gonadal structures [3].
In conclusion, ADAMTS9 plays essential roles in multiple biological processes. The gene knockout models in mice and zebrafish have revealed its importance in insulin-related metabolic processes and gonadal development. These findings contribute to our understanding of the molecular mechanisms underlying insulin resistance and gonadal development-related disorders [1,3].
References:
1. Graae, Anne-Sofie, Grarup, Niels, Ribel-Madsen, Rasmus, Hansen, Torben, Holst, Birgitte. 2019. ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations. In Diabetes, 68, 502-514. doi:10.2337/db18-0418. https://pubmed.ncbi.nlm.nih.gov/30626608/
2. Choi, Yo Jun, Halbritter, Jan, Braun, Daniela A, Gee, Heon Yung, Hildebrandt, Friedhelm. . Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. In American journal of human genetics, 104, 45-54. doi:10.1016/j.ajhg.2018.11.003. https://pubmed.ncbi.nlm.nih.gov/30609407/
3. Carter, Nichole Jansch, Roach, Zachary Adam, Byrnes, Mckenzie Marie, Zhu, Yong. 2019. Adamts9 is necessary for ovarian development in zebrafish. In General and comparative endocrinology, 277, 130-140. doi:10.1016/j.ygcen.2019.04.003. https://pubmed.ncbi.nlm.nih.gov/30951722/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen