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C57BL/6JCya-Carns1em1flox/Cya
Common Name:
Carns1-flox
Product ID:
S-CKO-00553
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Carns1-flox
Strain ID
CKOCMP-107239-Carns1-B6J-VA
Gene Name
Carns1
Product ID
S-CKO-00553
Gene Alias
Atpgd1; mKIAA1394
Background
C57BL/6JCya
NCBI ID
107239
Modification
Conditional knockout
Chromosome
19
Phenotype
MGI:2147595
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Carns1em1flox/Cya mice (Catalog S-CKO-00553) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000167055
NCBI RefSeq
NM_134148
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Carnos1, or carnosine synthase 1, is an enzyme that catalyzes the synthesis of carnosine, a histidine-containing dipeptide with antiproliferative activity in cancer [1]. It is involved in multiple biological processes and pathways, such as being present in oligodendrocytes and contributing to the regulation of oxidative stress, and may also play a role in the regulation of arginine metabolism [2,3,5].

Gene knockout models have provided significant insights into Carns1 function. In Carns1-KO mice, there are lower numbers of mature oligodendrocytes, increased lipid peroxidation, and behavioral changes, suggesting that Carns1-synthesized histidine dipeptides protect oligodendrocytes from oxidative stress [3]. In the context of multiple sclerosis, Carns1 expression is diminished in demyelinated lesions, and Carns1-KO mice display exaggerated neuroinflammation and clinical symptoms, indicating that loss of Carns1 can aggravate disease progression [2]. In a CARNS1 -/- rat model, cardiac muscle contractile function is significantly impaired, showing that histidine-containing dipeptides synthesized by CARNS1 are key regulators of excitation-contraction coupling in cardiac muscle [4].

In summary, Carns1 is crucial for the synthesis of histidine-containing dipeptides that protect oligodendrocytes from oxidative stress, maintain normal cardiac muscle function, and may impact disease processes such as multiple sclerosis. Gene knockout models, like Carns1-KO mice and CARNS1 -/- rats, have been instrumental in revealing these functions, providing valuable insights into the role of Carns1 in various biological processes and disease conditions.

References:
1. Zhang, Li, Zhang, Yan, Zhang, Xin, He, Miao, Qiao, Shixing. 2021. Combining bioinformatics analysis and experiments to explore CARNS1 as a prognostic biomarker for breast cancer. In Molecular genetics & genomic medicine, 9, e1586. doi:10.1002/mgg3.1586. https://pubmed.ncbi.nlm.nih.gov/33533160/
2. Spaas, Jan, Van der Stede, Thibaux, de Jager, Sarah, Eijnde, Bert O, Derave, Wim. 2023. Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis. In Progress in neurobiology, 231, 102532. doi:10.1016/j.pneurobio.2023.102532. https://pubmed.ncbi.nlm.nih.gov/37774767/
3. Sajrawi, Clara, Odeh, Maali, Tiwari, Akshay K, Engelender, Simone, Wolosker, Herman. 2024. Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivo. In Glia, 73, 122-139. doi:10.1002/glia.24624. https://pubmed.ncbi.nlm.nih.gov/39360557/
4. Gonçalves, Lívia de Souza, Sales, Lucas Peixoto, Saito, Tiemi Raquel, Ferreira, Julio Cesar Batista, Artioli, Guilherme Giannini. 2021. Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: Evidence from a novel CARNS1 knockout rat model. In Redox biology, 44, 102016. doi:10.1016/j.redox.2021.102016. https://pubmed.ncbi.nlm.nih.gov/34038814/
5. Miao, Jing, Li, Fengyang, Zhang, Meina, Li, Na, Lei, Liancheng. 2022. Carnosine Synthase 1 Contributes to Interferon Gamma-Induced Arginine Depletion via Mitogen-activated Protein Kinase 11 Signaling in Bovine Mammary Epithelial Cells. In Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 42, 501-512. doi:10.1089/jir.2022.0025. https://pubmed.ncbi.nlm.nih.gov/35900262/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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