C57BL/6JCya-Slc25a45em1flox/Cya
Common Name:
Slc25a45-flox
Product ID:
S-CKO-00566
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Slc25a45-flox
Strain ID
CKOCMP-107375-Slc25a45-B6J-VA
Gene Name
Product ID
S-CKO-00566
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc25a45em1flox/Cya mice (Catalog S-CKO-00566) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025732
NCBI RefSeq
NM_134154
Target Region
Exon 5~6
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Slc25a45, a member of the mitochondrial solute carrier family 25, is involved in transporting molecules across the mitochondrial membrane [3]. It may play roles in various biological processes such as metabolism, given its mitochondrial association, and is potentially linked to pathways related to energy production within the mitochondria. Genetic models could be valuable for studying its functions in depth.
In one study, in tissue transglutaminase (TG2) knock-out mice, preadipocytes and beige cells from epididymal fat had decreased expression of Slc25a45, along with other solute carrier proteins. This led to multiple mitochondrial impairments like altered electron transport, reduced oxygen consumption, and lower UCP1 protein content, suggesting Slc25a45 is important for normal mitochondrial function in thermogenesis [1]. In prenatal testosterone-treated female sheep, the expression of Slc25a45 was downregulated, and it was identified as a potential biomarker of prenatal testosterone excess, indicating its role in metabolic dysregulation [2].
In conclusion, Slc25a45 is essential for mitochondrial functions as demonstrated by model-based research. Its downregulation in certain models is associated with metabolic dysregulation and abnormal mitochondrial function in processes like thermogenesis. Understanding Slc25a45 could potentially provide insights into metabolic-related diseases and mitochondrial-associated disorders.
References:
1. Lénárt, Kinga, Bankó, Csaba, Ujlaki, Gyula, Fésüs, László, Mádi, András. 2022. Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis. In International journal of molecular sciences, 23, . doi:10.3390/ijms23095175. https://pubmed.ncbi.nlm.nih.gov/35563567/
2. Saadat, Nadia, Puttabyatappa, Muraly, Elangovan, Venkateswaran R, Bakulski, Kelly M, Padmanabhan, Vasantha. . Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Noncoding RNA in Female Sheep. In Endocrinology, 163, . doi:10.1210/endocr/bqab225. https://pubmed.ncbi.nlm.nih.gov/34718504/
3. Haitina, Tatjana, Lindblom, Jonas, Renström, Thomas, Fredriksson, Robert. 2006. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. In Genomics, 88, 779-790. doi:10.1016/j.ygeno.2006.06.016. https://pubmed.ncbi.nlm.nih.gov/16949250/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen