C57BL/6JCya-Adgrb1em1flox/Cya
Common Name:
Adgrb1-flox
Product ID:
S-CKO-00611
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Adgrb1-flox
Strain ID
CKOCMP-107831-Adgrb1-B6J-VA
Gene Name
Product ID
S-CKO-00611
Gene Alias
B830018M07Rik; Bai1; mKIAA4089
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adgrb1em1flox/Cya mice (Catalog S-CKO-00611) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000042035
NCBI RefSeq
NM_174991
Target Region
Exon 19
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Adgrb1, also known as BAI1, is an adhesion G protein-coupled receptor. It plays significant roles in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor. It is also crucial for dendritic spine and excitatory synapse development, interacting with autism-relevant proteins. It may be involved in pathways related to synaptic function, axon guidance, and synapse assembly [1,2].
In Adgrb1 mutant mice, homozygous (Adgrb1-/-) mice show significant social behavior deficits, increased seizure susceptibility, delayed growth, reduced brain weight, reduced neuron density, and increased apoptosis in the hippocampus during brain development [2]. Additionally, a genetic variant near Adgrb1, rs4129585, may regulate Adgrb1 and is associated with schizophrenia risk, as genes related to its alleles are interconnected in synaptic-related pathways [3,4].
In conclusion, Adgrb1 is essential for multiple biological processes, especially those related to brain development and function. The study of Adgrb1 using gene-knockout mouse models has revealed its significance in social behavior, seizure susceptibility, and brain morphology, as well as its potential association with schizophrenia. These findings contribute to understanding the biological functions of Adgrb1 and its implications in related diseases.
References:
1. Hamann, Jörg, Aust, Gabriela, Araç, Demet, Langenhan, Tobias, Schiöth, Helgi B. . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. In Pharmacological reviews, 67, 338-67. doi:10.1124/pr.114.009647. https://pubmed.ncbi.nlm.nih.gov/25713288/
2. Shiu, Fu Hung, Wong, Jennifer C, Yamamoto, Takahiro, Hall, Randy A, Escayg, Andrew. 2022. Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development. In Experimental neurology, 351, 113994. doi:10.1016/j.expneurol.2022.113994. https://pubmed.ncbi.nlm.nih.gov/35114205/
3. Wahbeh, Marah H, Boyd, Rachel J, Yovo, Christian, McCallion, Andrew S, Avramopoulos, Dimitrios. 2023. A Functional Schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.12.18.570831. https://pubmed.ncbi.nlm.nih.gov/38187620/
4. Wahbeh, Marah H, Boyd, Rachel J, Yovo, Christian, McCallion, Andrew S, Avramopoulos, Dimitrios. 2024. A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes. In HGG advances, 5, 100303. doi:10.1016/j.xhgg.2024.100303. https://pubmed.ncbi.nlm.nih.gov/38702885/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen