C57BL/6JCya-Rarres1em1flox/Cya
Common Name:
Rarres1-flox
Product ID:
S-CKO-00756
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rarres1-flox
Strain ID
CKOCMP-109222-Rarres1-B6J-VA
Gene Name
Product ID
S-CKO-00756
Gene Alias
5430417P09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rarres1em1flox/Cya mice (Catalog S-CKO-00756) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000054825
NCBI RefSeq
NM_001164763
Target Region
Exon 3
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Rarres1, retinoic acid receptor responder protein 1, is a gene involved in various biological processes. It has been associated with functions such as regulating mitochondrial and fatty acid metabolism, stem cell differentiation, and cell survival [2,3]. Rarres1 may also play a role in pathways related to tubulin deglutamylation, which in turn impacts mitochondrial function and energy balance [3].
In mouse models, the constitutive knockout of Rarres1 (Rarres1 -/-) led to a markedly increased dose-dependent incidence of follicular lymphoma (FL) and inhibited B cell differentiation. Prior to lymphoma formation, Rarres1 -/- B cells had compromised activation, maturation, and cell cycle progression [2]. In the context of kidney diseases, podocyte-specific overexpression of RARRES1 in mice resulted in marked glomerular injury and albuminuria, while podocyte-specific knockdown of Rarres1 ameliorated glomerular injury in adriamycin-induced nephropathy [1].
In conclusion, Rarres1 plays crucial roles in multiple biological processes and diseases. Mouse models, especially gene knockout models, have significantly contributed to understanding its role in follicular lymphoma development, B cell differentiation, and glomerular disease progression. These findings provide insights into potential therapeutic targets for related diseases.
References:
1. Chen, Anqun, Feng, Ye, Lai, Han, Lee, Kyung, He, John Cijiang. . Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression. In The Journal of clinical investigation, 130, 5523-5535. doi:10.1172/JCI140155. https://pubmed.ncbi.nlm.nih.gov/32634130/
2. Patel, Jay, Xun, Dan, Creswell, Karen, Byers, Stephen W, Lee, Mi-Hye. 2022. Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice. In International journal of biological sciences, 18, 2670-2682. doi:10.7150/ijbs.69615. https://pubmed.ncbi.nlm.nih.gov/35541897/
3. Maimouni, Sara, Lee, Mi-Hye, Sung, You-Me, Kumar, Deepak, Byers, Stephen. 2019. Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. In Oncotarget, 10, 1606-1624. doi:10.18632/oncotarget.26600. https://pubmed.ncbi.nlm.nih.gov/30899431/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen