C57BL/6NCya-Lmo1em1flox/Cya
Common Name:
Lmo1-flox
Product ID:
S-CKO-00784
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lmo1-flox
Strain ID
CKOCMP-109594-Lmo1-B6N-VA
Gene Name
Product ID
S-CKO-00784
Gene Alias
Rbtn-1; Rbtn1; Ttg1
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Lmo1em1flox/Cya mice (Catalog S-CKO-00784) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000036992
NCBI RefSeq
NM_057173
Target Region
Exon 3~4
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
LMO1, also known as LIM domain only protein1, is a nuclear transcription coregulator. It has been implicated in the pathogenesis of multiple cancers. LMO1 may be involved in pathways like NF-κB pathway [2].
In neuroblastoma, certain LMO1 polymorphisms (rs110419, rs2168101, rs4758051, rs10840002) are associated with a decreased risk, while rs204938 shows a positive association with susceptibility [1]. In glioma, high LMO1 expression is linked to high tumor grade and poor prognosis, and LMO1 promotes tumor growth, invasion and migration through the LMO1-NGFR-NF-κB axis [2]. In Wilms tumor, the rs2168101 G>T polymorphism has a protective effect [3]. In zebrafish, LMO1 synergizes with MYCN to promote neuroblastoma initiation, progression and metastasis [4]. In colorectal cancer, LMO1 promotes cell proliferation and is a predictive marker for anti-EGFR therapy [5]. In lung cancer, LMO1 promotes cell proliferation, is correlated with neuroendocrine differentiation, and high LMO1 mRNA level predicts poor patient survival [6].
In conclusion, LMO1 plays an oncogenic role in multiple cancers including glioma, neuroblastoma, colorectal cancer and lung cancer. Its polymorphisms are associated with the risk of neuroblastoma and Wilms tumor. Research on LMO1 helps to understand cancer pathogenesis and may provide potential targets for cancer treatment.
References:
1. Hashemi, Mohammad, Sarabandi, Sahel, Karami, Shima, Ghavami, Saeid, Łos, Marek J. 2019. LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies. In Journal of cellular and molecular medicine, 24, 1160-1168. doi:10.1111/jcmm.14836. https://pubmed.ncbi.nlm.nih.gov/31830377/
2. Gao, Lei, Wu, Jia, Wang, Hai, Peng, Yuping, Li, Yaomin. 2022. LMO1 Plays an Oncogenic Role in Human Glioma Associated With NF-kB Pathway. In Frontiers in oncology, 12, 770299. doi:10.3389/fonc.2022.770299. https://pubmed.ncbi.nlm.nih.gov/35280742/
3. Li, Guoyuan, Jia, Wei, Yin, Zijun, He, Jing, Fu, Wen. 2019. LMO1 Super-Enhancer rs2168101 G>T Polymorphism Reduces Wilms Tumor Risk. In Journal of Cancer, 10, 1808-1813. doi:10.7150/jca.29842. https://pubmed.ncbi.nlm.nih.gov/31205537/
4. Zhu, Shizhen, Zhang, Xiaoling, Weichert-Leahey, Nina, Maris, John M, Look, A Thomas. 2017. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. In Cancer cell, 32, 310-323.e5. doi:10.1016/j.ccell.2017.08.002. https://pubmed.ncbi.nlm.nih.gov/28867147/
5. Liu, Junguang, Yan, Peiyun, Jing, Niancai, Yang, Jili. 2014. LMO1 is a novel oncogene in colorectal cancer and its overexpression is a new predictive marker for anti-EGFR therapy. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35, 8161-7. doi:10.1007/s13277-014-2066-y. https://pubmed.ncbi.nlm.nih.gov/24845030/
6. Du, Liqin, Zhao, Zhenze, Suraokar, Milind, Wistuba, Ignacio, Pertsemlidis, Alexander. 2018. LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. In Oncotarget, 9, 29601-29618. doi:10.18632/oncotarget.25642. https://pubmed.ncbi.nlm.nih.gov/30038707/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen