C57BL/6NCya-Acheem1flox/Cya
Common Name:
Ache-flox
Product ID:
S-CKO-00963
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ache-flox
Strain ID
CKOCMP-11423-Ache-B6N-VA
Gene Name
Product ID
S-CKO-00963
Gene Alias
--
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Acheem1flox/Cya mice (Catalog S-CKO-00963) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024099
NCBI RefSeq
NM_009599
Target Region
Exon 2~3
Size of Effective Region
~2.5 kb
Detailed Document
Overview of Gene Research
Ache, also known as Acetylcholinesterase, is a key enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine, terminating its action in cholinergic synapses. This process is crucial for normal neurotransmission in the nervous system, and it is involved in pathways related to muscle function, memory, and learning. Genetic models, especially gene knockout (KO) and conditional knockout (CKO) mouse models, are valuable tools for studying Ache's functions [1].
However, among the provided references, there is no content directly related to Ache from KO/CKO mouse models or other loss-of-function experiments.
In conclusion, Ache is essential for normal neurotransmission by hydrolyzing acetylcholine. Although the provided references do not offer insights from relevant mouse models, such models are generally important for revealing Ache's role in specific biological processes and disease conditions related to the nervous system and muscle function.
References:
1. Arzhan, Soraya, Roumelioti, Maria-Eleni, Unruh, Mark L. 2019. Itch and Ache on Dialysis: New Approaches to Manage Uremic Pruritus and Restless Legs. In Blood purification, 49, 222-227. doi:10.1159/000504081. https://pubmed.ncbi.nlm.nih.gov/31851986/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen