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C57BL/6JCya-Adipoqem1flox/Cya
Common Name:
Adipoq-flox
Product ID:
S-CKO-00986
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Adipoq-flox
Strain ID
CKOCMP-11450-Adipoq-B6J-VA
Gene Name
Adipoq
Product ID
S-CKO-00986
Gene Alias
30kDa; APN; Acdc; Acrp30; Ad; Adid; GBP28; adipo; apM1
Background
C57BL/6JCya
NCBI ID
11450
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:106675
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adipoqem1flox/Cya mice (Catalog S-CKO-00986) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023593
NCBI RefSeq
NM_009605
Target Region
Exon 3
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Adipoq, encoding adiponectin, is a gene with a preponderant role in the homeostasis of glucose and fatty acids. Adiponectin is a fat-derived protein hormone, and its associated pathways likely involve energy metabolism, glucose and lipid regulation, which are crucial for overall metabolic health [2]. Genetic models, such as gene knockout (KO) or conditional knockout (CKO) mouse models, can be valuable for studying Adipoq's function.

In bone marrow, Adipoq-lineage progenitors (cells expressing Adipoq) are a major cellular source of M-CSF. Deficiency of M-CSF in bone marrow Adipoq-lineage progenitors in mice drastically reduces the generation of bone marrow macrophages and osteoclasts, leading to severe osteopetrosis. Also, osteoporosis in ovariectomized mice can be significantly alleviated by the absence of M-CSF in these progenitors, revealing their crucial contribution to bone homeostasis and pathological bone loss [1]. Depletion of Shn3 in Adipoq-lineage progenitors in mice results in a significant increase in trabecular bone mass and bone formation in vivo, and enhances bone fracture healing under pathological conditions, suggesting a role of Adipoq-lineage progenitors in osteogenesis [3].

In conclusion, Adipoq is essential for metabolic homeostasis, especially in glucose and fatty acid regulation. Mouse models with genetic manipulation of Adipoq-lineage progenitors have revealed its significance in bone-related biological processes, such as bone marrow macrophage development, osteoclastogenesis, and bone mass regulation, providing insights into potential treatments for bone-loss related disorders [1,3].

References:
1. Inoue, Kazuki, Qin, Yongli, Xia, Yuhan, Greenblatt, Matthew B, Zhao, Baohong. 2023. Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass. In eLife, 12, . doi:10.7554/eLife.82118. https://pubmed.ncbi.nlm.nih.gov/36779851/
2. Reyes Leon-Cachon, Rafael Baltazar, Salinas-Santander, Mauricio Andres, Alejandra Aguilar-Tamez, Daniela, de Jesus Suarez-Valencia, Victor, Morlett-Chavez, Jesus Antonio. 2022. ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents. In Journal of applied biomedicine, 20, 146-153. doi:10.32725/jab.2022.017. https://pubmed.ncbi.nlm.nih.gov/36708720/
3. Li, Zan, Zeng, Xiangchen, Shi, Baohong, Huang, Jianming, Xu, Ren. 2024. Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow. In Journal of orthopaedic translation, 45, 168-177. doi:10.1016/j.jot.2024.01.008. https://pubmed.ncbi.nlm.nih.gov/38549808/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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