Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Adss2em1flox/Cya
Common Name:
Adss2-flox
Product ID:
S-CKO-01089
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Adss2-flox
Strain ID
CKOCMP-11566-Adss2-B6J-VA
Gene Name
Adss2
Product ID
S-CKO-01089
Gene Alias
AS; Adss; adSS 2
Background
C57BL/6JCya
NCBI ID
11566
Modification
Conditional knockout
Chromosome
1
Phenotype
MGI:87948
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adss2em1flox/Cya mice (Catalog S-CKO-01089) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000016105
NCBI RefSeq
NM_007422
Target Region
Exon 2~4
Size of Effective Region
~2.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Adss2, adenylosuccinate synthase 2, is one of the two isozymes of adenylosuccinate synthetase which catalyzes a key step in AMP synthesis. It is widely distributed in various tissues in pigs [1]. In cardiac myocytes, electrical stimulation represses the expression of Adss2, while activating the muscle-specific Adss1 isoform [4].

In pigs, a single nucleotide polymorphism (SNP, T/C(70)) in the ninth intron of Adss2 gene was significantly associated with average daily gain trait and loin muscle area trait [1]. In bladder cancer, SNP-SNP interactions located in ST7L-Adss2 were identified, some of which were positively or negatively associated with BC risk in different ethnic groups [2]. Also, alleles near Adss2 gene showed significant parent-of-origin effects in childhood asthma, with the maternally inherited G-allele at rs3003214 potentially contributing to the maternal effect in childhood asthma [3]. In tamoxifen-resistant invasive lobular carcinoma cells, the expression of Adss2 was increased, along with other nucleic acid biosynthesis enzymes [5].

In summary, Adss2 is involved in nucleotide biosynthesis and has associations with various traits and diseases such as growth-related traits in pigs, bladder cancer, childhood asthma, and tamoxifen-resistant invasive lobular carcinoma. These findings from different genetic association studies help to understand the role of Adss2 in specific biological processes and disease conditions.

References:
1. Li, Xinyun, Zhu, Zhengmao, Mo, Delin, Zhao, Shuhong, Li, Kui. 2007. Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa). In Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 147, 271-7. doi:. https://pubmed.ncbi.nlm.nih.gov/17347008/
2. Yu, Evan Yi-Wen, Tang, Qiu-Yi, Chen, Ya-Ting, Zeegers, Maurice P, Wesselius, Anke. 2023. Genome-wide exploration of genetic interactions for bladder cancer risk. In International journal of cancer, 154, 81-93. doi:10.1002/ijc.34690. https://pubmed.ncbi.nlm.nih.gov/37638657/
3. Lee, Yunsung, Gjerdevik, Miriam, Jugessur, Astanand, Håberg, Siri Eldevik, Magnus, Per. . Parent-of-Origin Effects in Childhood Asthma at Seven Years of Age. In Genetic epidemiology, 49, e70007. doi:10.1002/gepi.70007. https://pubmed.ncbi.nlm.nih.gov/40133993/
4. Xia, Y, McMillin, J B, Lewis, A, Williams, R S, Kellems, R E. . Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. In The Journal of biological chemistry, 275, 1855-63. doi:. https://pubmed.ncbi.nlm.nih.gov/10636885/
5. Gupta, Annapurna, Choueiry, Fouad, Reardon, Jesse, Ramaswamy, Bhuvaneswari, Majumder, Sarmila. 2025. Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance. In bioRxiv : the preprint server for biology, , . doi:10.1101/2025.01.16.633236. https://pubmed.ncbi.nlm.nih.gov/39868332/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest