C57BL/6NCya-Amhem1flox/Cya
Common Name:
Amh-flox
Product ID:
S-CKO-01180
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Amh-flox
Strain ID
CKOCMP-11705-Amh-B6N-VA
Gene Name
Product ID
S-CKO-01180
Gene Alias
MIS
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Amhem1flox/Cya mice (Catalog S-CKO-01180) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000036016
NCBI RefSeq
NM_007445
Target Region
Exon 2~5
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Amh, also known as Anti-Müllerian Hormone, is a critical glycoprotein. In male fetuses, it drives the involution of the Müllerian ducts during sexual differentiation, preventing the development of female reproductive structures like the uterus and Fallopian tubes [5]. In females, it is produced by the granulosa cells of small antral follicles in the ovaries and functions as an autocrine and paracrine regulator of follicular maturation [2].
In the context of female fertility, Amh is widely used as a biomarker of ovarian reserve. Serum Amh levels correlate with the number of growing follicles, helping estimate ovarian reserve, determine dosing in ovarian stimulation, and predict stimulation response. However, it does not reflect oocyte health or the chances of pregnancy [1,6]. In domestic animals, it can be a reliable reproductive marker for fertility competence and a predictor of superovulation [3]. In pediatric disorders of sex development, serum Amh measurement aids in differential diagnosis. For example, in undervirilized 46,XY DSD, low Amh levels suggest gonadal dysgenesis, while normal or high levels are seen in androgen-related defects. In 46,XX newborns, it can detect the presence of testicular tissue, leading to the diagnosis of ovotesticular DSD [4].
In conclusion, Amh plays essential roles in sexual differentiation, ovarian function, and fertility in both humans and animals. Its measurement is valuable in various clinical scenarios, such as assessing female fertility potential, diagnosing disorders of sex development, and predicting reproductive outcomes in domestic animals. Research on Amh, including through gene-based models in the future, can further our understanding of these biological processes and potentially lead to improved diagnostic and treatment strategies.
References:
1. Cedars, Marcelle I. . Evaluation of Female Fertility-AMH and Ovarian Reserve Testing. In The Journal of clinical endocrinology and metabolism, 107, 1510-1519. doi:10.1210/clinem/dgac039. https://pubmed.ncbi.nlm.nih.gov/35100616/
2. Shrikhande, Laxmi, Shrikhande, Bhushan, Shrikhande, Aditya. 2020. AMH and Its Clinical Implications. In Journal of obstetrics and gynaecology of India, 70, 337-341. doi:10.1007/s13224-020-01362-0. https://pubmed.ncbi.nlm.nih.gov/33041549/
3. Umer, Saqib, Zhao, Shan Jiang, Sammad, Abdul, Yunwei, Pang, Zhu, Huabin. 2019. AMH: Could It Be Used as A Biomarker for Fertility and Superovulation in Domestic Animals? In Genes, 10, . doi:10.3390/genes10121009. https://pubmed.ncbi.nlm.nih.gov/31817280/
4. Josso, Nathalie, Rey, Rodolfo A. 2020. What Does AMH Tell Us in Pediatric Disorders of Sex Development? In Frontiers in endocrinology, 11, 619. doi:10.3389/fendo.2020.00619. https://pubmed.ncbi.nlm.nih.gov/33013698/
5. Edelsztein, Nadia Y, Valeri, Clara, Lovaisa, María M, Schteingart, Helena F, Rey, Rodolfo A. 2022. AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications. In Frontiers in endocrinology, 13, 906381. doi:10.3389/fendo.2022.906381. https://pubmed.ncbi.nlm.nih.gov/35712256/
6. Moolhuijsen, Loes M E, Visser, Jenny A. . Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. In The Journal of clinical endocrinology and metabolism, 105, 3361-73. doi:10.1210/clinem/dgaa513. https://pubmed.ncbi.nlm.nih.gov/32770239/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen