C57BL/6JCya-Ivns1abpem1flox/Cya
Common Name
Ivns1abp-flox
Product ID
S-CKO-01195
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-117198-Ivns1abp-B6J-VA
When using this mouse strain in a publication, please cite “Ivns1abp-flox Mouse (Catalog S-CKO-01195) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ivns1abp-flox
Strain ID
CKOCMP-117198-Ivns1abp-B6J-VA
Gene Name
Product ID
S-CKO-01195
Gene Alias
1190004M08Rik, 1700126I16Rik, HSPC068, ND1, NS-1, NS1-BP, Nd1-L, Nd1-S, mKIAA0850
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023918
NCBI RefSeq
NM_054102
Target Region
Exon 9~14
Size of Effective Region
~2.7 kb
Overview of Gene Research
Ivns1abp, also known as Influenza Virus NS1A Binding Protein, belongs to the Kelch family of proteins. It plays a central role in actin cytoskeleton dynamics by directly associating with F-actin and protecting against actin derangement. It is involved in modulating macrophages' response to cytokines and phagocytic potential in inflammation, and may be a critical regulator of the macrophage phenotype and function under inflammatory conditions [3].
A whole-genome sequencing analysis in a primary immunodeficiency (PID) cohort identified Ivns1abp as a new candidate PID-associated gene, suggesting its potential role in immune-related processes [1]. In gastric cancer, circDUSP16 acts as a sponge of miR-145-5p, which attenuates circDUSP16-induced IVNS1ABP expression, indicating its involvement in tumor-related mechanisms [2]. In shrimp, acute hypoxia stress up-regulates Ivns1abp, and this may be related to the impact of hypoxia on immune-related gene expression and susceptibility to Vibrio parahaemolyticus infection [4].
In conclusion, Ivns1abp is involved in multiple biological processes such as immune-related responses, macrophage function in inflammation, and tumor-associated mechanisms. Its role in these areas, as revealed through various research models, provides insights into understanding related biological functions and disease mechanisms.
References：
1. Thaventhiran, James E D, Lango Allen, Hana, Burren, Oliver S, Thrasher, Adrian J, Smith, Kenneth G C. 2020. Whole-genome sequencing of a sporadic primary immunodeficiency cohort. In Nature, 583, 90-95. doi:10.1038/s41586-020-2265-1. https://pubmed.ncbi.nlm.nih.gov/32499645/
2. Zhang, Zizhen, Wang, Chaojie, Zhang, Yeqian, Zhao, Gang, Xu, Jia. 2019. CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p. In Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23, 437-448. doi:10.1007/s10120-019-01018-7. https://pubmed.ncbi.nlm.nih.gov/31776711/
3. Hotter, Georgina, Mastora, Chrysoula, Jung, Michaela, Guiteras, Roser, Sola, Anna. 2020. The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation. In Scientific reports, 10, 15302. doi:10.1038/s41598-020-72342-7. https://pubmed.ncbi.nlm.nih.gov/32943673/
4. He, Honghui, Huang, Shaoqing, Geng, Ningze, He, Jianguo, Li, Chaozheng. 2024. Acute hypoxia stress mediates HIF-1α-Yki-Cactus axis to facilitate the infection of Vibrio parahaemolyticus in Litopenaeus vannamei. In Frontiers in immunology, 15, 1476309. doi:10.3389/fimmu.2024.1476309. https://pubmed.ncbi.nlm.nih.gov/39664389/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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