Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Bmal1em1flox/Cya
Common Name:
Bmal1-flox
Product ID:
S-CKO-01309
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Bmal1-flox
Strain ID
CKOCMP-11865-Bmal1-B6J-VA
Gene Name
Bmal1
Product ID
S-CKO-01309
Gene Alias
Arnt3; Arntl; BMAL1b; MOP3; bHLHe5; bmal1b'
Background
C57BL/6JCya
NCBI ID
11865
Modification
Conditional knockout
Chromosome
7
Phenotype
MGI:1096381
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Bmal1em1flox/Cya mice (Catalog S-CKO-01309) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047321
NCBI RefSeq
NM_007489
Target Region
Exon 6~8
Size of Effective Region
~2.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Bmal1, also known as Brain and muscle arnt-like protein 1, is a crucial transcription factor and a core component of the circadian oscillation. It forms a heterodimer with Clock, binding to the E-box element in the promoters of genes like Per and Cry, regulating the rhythmic expression of circadian clock-controlled genes. Bmal1 is involved in maintaining immune homeostasis, and is associated with pathways related to metabolism, immunity, and reproduction, playing an overall vital role in various biological processes [2].

In disease-related studies, Bmal1 down-regulation in cardiomyocyte-specific knockout (CKB) and type 2 diabetes (T2D) mice hearts accelerates cardiac hypertrophy and diastolic dysfunction, while overexpression alleviates these pathological changes in diabetic cardiomyopathy (DCM), suggesting its role in DCM development through Bcl2/IP3R-mediated mitochondrial Ca2+ overload [1]. In Bmal1 -/- mutant mice (a model with non-functional circadian clock), colitis is more severe, with constant disease activity, impaired recovery, and loss of daily rhythms in inflammation and epithelial proliferation, indicating Bmal1's importance in regulating the daily timing of colitis [3]. In AML, knocking down BMAL1 inhibits cell growth by blocking the cell cycle and promotes ferroptosis, enhancing the efficacy of certain cancer therapeutic drugs, as BMAL1 up-regulation is observed in AML patients with poor prognosis [4].

In conclusion, Bmal1 is essential for maintaining normal physiological functions related to circadian rhythms, immune homeostasis, and metabolism. The use of gene knockout (KO) and conditional knockout (CKO) mouse models has revealed its significant roles in diseases such as DCM, colitis, and AML, providing potential therapeutic targets for these diseases.

References:
1. Zhang, Nannan, Yu, Hao, Liu, Tianzi, Hou, Xiaofeng, Zou, Jiangang. 2023. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca2+ overload. In Redox biology, 64, 102788. doi:10.1016/j.redox.2023.102788. https://pubmed.ncbi.nlm.nih.gov/37356134/
2. Fan, Xu-Li, Song, Ying, Qin, Dong-Xu, Lin, Pei-Yao. 2021. Regulatory Effects of Clock and Bmal1 on Circadian Rhythmic TLR Expression. In International reviews of immunology, 42, 101-112. doi:10.1080/08830185.2021.1931170. https://pubmed.ncbi.nlm.nih.gov/34544330/
3. Taleb, Zainab, Carmona-Alcocer, Vania, Stokes, Kyle, Khan, Waliul I, Karpowicz, Phillip. 2022. BMAL1 Regulates the Daily Timing of Colitis. In Frontiers in cellular and infection microbiology, 12, 773413. doi:10.3389/fcimb.2022.773413. https://pubmed.ncbi.nlm.nih.gov/35223537/
4. Zheng, Hong, Wu, Ting, Lin, Zhi, Li, Jia-Da, Yang, Minghua. 2024. Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway. In Journal of cancer research and clinical oncology, 150, 231. doi:10.1007/s00432-024-05753-y. https://pubmed.ncbi.nlm.nih.gov/38703241/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest