C57BL/6JCya-Bmpr1bem1flox/Cya
Common Name:
Bmpr1b-flox
Product ID:
S-CKO-01441
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Bmpr1b-flox
Strain ID
CKOCMP-12167-Bmpr1b-B6J-VA
Gene Name
Product ID
S-CKO-01441
Gene Alias
ALK-6; Acvrlk6; Alk6; BMPR-1B; BMPR-IB; CFK-43a; SKR6
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Bmpr1bem1flox/Cya mice (Catalog S-CKO-01441) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029948
NCBI RefSeq
NM_007560
Target Region
Exon 3~4
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Bmpr1b, short for Bone morphogenetic protein receptor type 1B, is a multifunctional signaling molecule in the canonical bone morphogenetic protein (BMP)/Sma-and mad-related protein (Smad) signaling pathway. It is well-known as the first major gene associated with sheep prolificacy [5]. Bmpr1b also plays a role in ovarian function and folliculogenesis in mammals, and its disruption is related to primary ovarian insufficiency (POI) [2,3].
In sheep, the FecB mutation in Bmpr1b, located near the binding site of the small molecule repressor protein FKBP1A, may increase the ovulation rate by affecting the intensity of the interactions between Bmpr1b and FKBP1A, thus changing the activity in the BMP/SMAD pathway [1]. In human studies, missense mutations in Bmpr1b lead to an impairment of downstream BMP signaling, unveiling a link between Bmpr1b variants and the origin of POI [3]. Also, Bmpr1b mutations are likely a cause of Pierre Robin sequence [4]. Additionally, Bmpr1b polymorphisms are associated with breast cancer susceptibility in Chinese Han women [6], and the lncRNA SNHG6/miR-125b-5p/Bmpr1b axis may be a new therapeutic target for triple-negative breast cancer [7]. In sheep granulosa cells, miR-1306 can inhibit Bmpr1b and promote cell apoptosis, potentially improving sheep fecundity [8]. In endometriosis patients, the lncRNA BMPR1B-AS1, regulated by IGF2BP2, affects decidualization through the SMAD1/5/9 pathway [9]. Genetically defined Bmpr1b-labeled DRG neurons are involved in mediating behavioral responses to high colon distension and over-reactivity in a model of inflammatory bowel disease [10].
In conclusion, Bmpr1b is crucial in multiple biological processes such as ovarian function, folliculogenesis, and sheep prolificacy. Its mutations and polymorphisms are associated with various diseases including POI, Pierre Robin sequence, and breast cancer. The study of Bmpr1b through different models helps in understanding the underlying molecular mechanisms of these biological processes and diseases, providing potential targets for diagnosis, treatment, and genetic improvement.
References：
1. Gong, Yi-Ming, Wang, Xiang-Yu, He, Xiao-Yun, Chu, Ming-Xing, Di, Ran. . Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep. In Yi chuan = Hereditas, 45, 295-305. doi:10.16288/j.yczz.22-366. https://pubmed.ncbi.nlm.nih.gov/37077164/
2. França, Monica Malheiros, Mendonca, Berenice Bilharinho. 2021. Genetics of ovarian insufficiency and defects of folliculogenesis. In Best practice & research. Clinical endocrinology & metabolism, 36, 101594. doi:10.1016/j.beem.2021.101594. https://pubmed.ncbi.nlm.nih.gov/34794894/
3. Renault, Lucie, Patiño, Liliana C, Magnin, Françoise, Binart, Nadine, Beau, Isabelle. . BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency. In The Journal of clinical endocrinology and metabolism, 105, . doi:10.1210/clinem/dgz226. https://pubmed.ncbi.nlm.nih.gov/31769494/
4. Yang, Yongjia, Yuan, Jianying, Yao, Xu, Tu, Ming, Zhu, Yimin. . BMPR1B mutation causes Pierre Robin sequence. In Oncotarget, 8, 25864-25871. doi:10.18632/oncotarget.16531. https://pubmed.ncbi.nlm.nih.gov/28418932/
5. Abdurahman, Anwar, Du, Xing, Yao, Yilong, Aniwashi, Jueken, Li, Qifa. 2019. Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells. In International journal of molecular sciences, 20, . doi:10.3390/ijms20112732. https://pubmed.ncbi.nlm.nih.gov/31167348/
6. Zheng, Yi, Jiang, Xun, Wang, Meng, Kang, Huafeng, Chen, Lei. 2022. BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study. In Clinical breast cancer, 22, e641-e646. doi:10.1016/j.clbc.2022.02.011. https://pubmed.ncbi.nlm.nih.gov/35501253/
7. Lv, Yufei, Lv, Xiaohong, Yang, Huike, Zhang, Jianguo, Zhang, Yafang. 2021. LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer. In Frontiers in oncology, 11, 678474. doi:10.3389/fonc.2021.678474. https://pubmed.ncbi.nlm.nih.gov/34026654/
8. Abdurahman, Anwar, Aierken, Wusimanjiang, Zhang, Fei, Aniwashi, Jueken, Sulayman, Ablat. 2022. miR-1306 induces cell apoptosis by targeting BMPR1B gene in the ovine granulosa cells. In Frontiers in genetics, 13, 989912. doi:10.3389/fgene.2022.989912. https://pubmed.ncbi.nlm.nih.gov/36212145/
9. Que, Xiaohong, Ren, Lulu, Yang, Lin, Wu, Rongfeng, Chen, Qionghua. . Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38, e23622. doi:10.1096/fj.202302195R. https://pubmed.ncbi.nlm.nih.gov/38703029/
10. Wolfson, Rachel L, Abdelaziz, Amira, Rankin, Genelle, Sharma, Nikhil, Ginty, David D. . DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. In Cell, 186, 3368-3385.e18. doi:10.1016/j.cell.2023.07.007. https://pubmed.ncbi.nlm.nih.gov/37541195/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen