Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Serping1em1flox/Cya
Common Name:
Serping1-flox
Product ID:
S-CKO-01471
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Serping1-flox
Strain ID
CKOCMP-12258-Serping1-B6J-VA
Gene Name
Serping1
Product ID
S-CKO-01471
Gene Alias
C1 Inh; C1INH.; C1Inh; C1nh
Background
C57BL/6JCya
NCBI ID
12258
Modification
Conditional knockout
Chromosome
2
Phenotype
MGI:894696
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Serping1em1flox/Cya mice (Catalog S-CKO-01471) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023994
NCBI RefSeq
NM_009776
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Serping1, also known as the C1 inhibitor (C1INH) encoding gene, plays a crucial role in the body. C1INH is a protease inhibitor that is the major control of the kallikrein-kinin system and also inhibits the C1r/C1s in the C1 complex of the classical complement pathway, preventing its spontaneous activation [1,3,4]. It is essential for maintaining the balance of the coagulation, complement, contact systems, and fibrinolysis [2].

Mutations in Serping1 are responsible for hereditary angioedema (C1-INH-HAE), an autosomal dominant disorder. Over 700 mutation variants have been described, with different phenotypes associated with the variants. For example, some dysfunctional serpin variants fail to associate with proteases and present a residual 105-kDa species after incubation with target protease. Also, in conditions with low antigenic C1Inh, some patients present an intermediate C1-INH-HAE phenotype [1]. In addition, Serping1 mRNA is overexpressed in monocytes from HIV-1 + patients, and its expression levels correlate with viral load and CD4+ T-cell count, indicating its role in the innate immune response to HIV-1 infection [3].

In conclusion, Serping1 is vital for regulating key physiological systems such as the kallikrein-kinin and complement systems. Its mutations are strongly linked to hereditary angioedema, and it also plays a role in the immune response to HIV-1. Understanding Serping1 through research, potentially including gene knockout models in the future, could further clarify its functions and provide insights for treating related diseases.

References:
1. Ponard, Denise, Gaboriaud, Christine, Charignon, Delphine, Tosi, Mario, Drouet, Christian. 2019. SERPING1 mutation update: Mutation spectrum and C1 Inhibitor phenotypes. In Human mutation, 41, 38-57. doi:10.1002/humu.23917. https://pubmed.ncbi.nlm.nih.gov/31517426/
2. Sinnathamby, Evan S, Issa, Peter P, Roberts, Logan, Shekoohi, Sahar, Kaye, Alan D. 2023. Hereditary Angioedema: Diagnosis, Clinical Implications, and Pathophysiology. In Advances in therapy, 40, 814-827. doi:10.1007/s12325-022-02401-0. https://pubmed.ncbi.nlm.nih.gov/36609679/
3. Sanfilippo, C, Cambria, D, Longo, A, Malaguarnera, L, Di Rosa, Michelino. 2017. SERPING1 mRNA overexpression in monocytes from HIV+ patients. In Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66, 1107-1116. doi:10.1007/s00011-017-1091-x. https://pubmed.ncbi.nlm.nih.gov/28889214/
4. Grymová, Tereza, Grodecká, Lucie, Souček, Přemysl, Freiberger, Tomáš. 2019. SERPING1 exon 3 splicing variants using alternative acceptor splice sites. In Molecular immunology, 107, 91-96. doi:10.1016/j.molimm.2019.01.007. https://pubmed.ncbi.nlm.nih.gov/30685616/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest