C57BL/6NCya-Anxa2em1flox/Cya
Common Name:
Anxa2-flox
Product ID:
S-CKO-01504
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Anxa2-flox
Strain ID
CKOCMP-12306-Anxa2-B6N-VA
Gene Name
Product ID
S-CKO-01504
Gene Alias
Cal1h; PAP-IV; p36
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Anxa2em1flox/Cya mice (Catalog S-CKO-01504) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034756
NCBI RefSeq
NM_007585
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Anxa2, also known as Annexin A2, is a pleiotropic calcium-dependent phospholipid-binding protein. It is involved in various cellular processes such as vesicular transport, antioxidant defense, and actin remodeling [5]. It has been implicated in multiple pathways, for example, it activates the MYC-HIF1A-VEGF axis in esophageal cancer progression [1].
In non-alcoholic steatohepatitis (NASH), the p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis and fibrosis. The inhibition of p-STAT3 can suppress these processes, and over-expression of Anxa2 reverses this suppression [2]. In triple-negative breast cancer cells, ANXA2 is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness. ANXA2 knockdown increases sensitivity to doxorubicin [3]. In gastric cancer, the EphA2-YES1-ANXA2 pathway promotes cancer progression and metastasis [4].
In conclusion, Anxa2 is involved in a wide range of biological functions, especially in the context of various diseases including cancer and NASH. Gene-knockout or conditional-knockout mouse models, if available in future studies, could further clarify its role in these disease conditions, helping to understand its function in specific biological processes and potentially leading to new therapeutic strategies.
References：
1. Ma, Sai, Lu, Chen-Chen, Yang, Li-Yan, Zhang, Yu, Wang, Ming-Rong. 2018. ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis. In Journal of experimental & clinical cancer research : CR, 37, 183. doi:10.1186/s13046-018-0851-y. https://pubmed.ncbi.nlm.nih.gov/30081903/
2. Feng, Yun, Li, Wenhua, Wang, Zhuoya, Li, Zhenghong, Dong, Yuwei. 2022. The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis. In Journal of translational medicine, 20, 497. doi:10.1186/s12967-022-03692-1. https://pubmed.ncbi.nlm.nih.gov/36324154/
3. Koh, Minsoo, Lim, Hyesol, Jin, Hao, Lee, Myung-Shik, Moon, Aree. 2024. ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells. In Autophagy, 20, 659-674. doi:10.1080/15548627.2024.2305063. https://pubmed.ncbi.nlm.nih.gov/38290972/
4. Mao, Linfeng, Yuan, Weijie, Cai, Kaimei, Chen, Zhikang, Chen, Zihua. 2021. EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis. In Oncogene, 40, 3610-3623. doi:10.1038/s41388-021-01786-6. https://pubmed.ncbi.nlm.nih.gov/33941853/
5. Partevian, Suzanna A, Slominsky, Petr A, Shadrina, Maria I, Alieva, Anelya Kh. 2025. ANXA2 Protein and Its Role in Neurodegeneration Processes. In Life (Basel, Switzerland), 15, . doi:10.3390/life15030402. https://pubmed.ncbi.nlm.nih.gov/40141747/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen