Camk2g, encoding the gamma subunit of calcium/calmodulin-dependent protein kinase 2, is involved in multiple biological processes. It participates in signaling pathways such as the MPL-JAK2 pathway. CAMK2G is expressed throughout the brain and has been associated with neurodevelopmental disorders. Genetic models, especially knockout mouse models, are valuable for studying its functions [2,4,5].

In myelofibrosis, CAMK2G was identified as a novel therapeutic target. CAMK2G inhibition was effective against both JAK2 inhibitor-sensitive and resistant cells. In MPL W515L-induced MF model cells and mice, CAMK2G hetero knockout in primary bone marrow cells decreased colony-forming capacity, and inhibition with berbamine prolonged survival and reduced disease phenotypes [1]. In a Camk2g knockout mouse model, loss of CAMK2G affected motor function and innate behaviors like nest-building and marble burying, but had minimal impact on cognitive behavior [2]. In neuroblastoma, knockdown of CAMK2G inhibited neuronal differentiation and promoted migration [3].

In conclusion, model-based research reveals that CAMK2G plays important roles in biological processes such as hematopoiesis, neurodevelopment, and neuronal differentiation. The Camk2g knockout mouse models have contributed to understanding its roles in myelofibrosis and neurodevelopment-related behaviors, suggesting potential therapeutic implications for these disease areas [1,2].