C57BL/6JCya-Cbx3em1flox/Cya
Common Name
Cbx3-flox
Product ID
S-CKO-01578
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12417-Cbx3-B6J-VA
When using this mouse strain in a publication, please cite “Cbx3-flox Mouse (Catalog S-CKO-01578) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cbx3-flox
Strain ID
CKOCMP-12417-Cbx3-B6J-VA
Gene Name
Product ID
S-CKO-01578
Gene Alias
M32, HP1g
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000031862
NCBI RefSeq
NM_007624
Target Region
Exon 3
Size of Effective Region
~1.8 kb
Overview of Gene Research
Cbx3, also known as HP1γ, is a heterochromatin-associated protein that plays significant roles in multiple biological processes. It is involved in epigenetic regulation, such as histone modifications, and interacts with various key pathways including PI3K/AKT, Ras/KRAS, Wnt/β -catenin, MAPK, Notch, and p53, influencing cell proliferation, apoptosis, and therapy resistance [3].
In glioblastoma, lactate-induced histone lactylation is regulated by Cbx3, leading to immunosuppressive transcriptional programs and immune evasion. Targeting Cbx3 inhibits tumor growth [1]. In prostate cancer, Cbx3 is upregulated in CDK4/6 inhibitor-resistant cells, and a dual BET/PLK1 inhibitor can increase the sensitivity of CRPC cells to CDK4/6 inhibitors partially through Cbx3 [2]. In clear cell renal carcinoma, Cbx3 promotes tumor advancement via PI3K/AKT activation and immunological dysregulation [4]. In colorectal carcinoma, Cbx3 promotes multidrug resistance by suppressing ferroptosis via the CUL3/NRF2/GPX2 axis [5]. In hepatocellular carcinoma, Cbx3 promotes development by regulating cell cycle progression and is regulated by miR-139 [6]. In glioblastoma multiforme, Cbx3 accelerates malignant progression by stabilizing EGFR expression [7].
In conclusion, Cbx3 is a crucial epigenetic regulator involved in multiple biological processes and diseases. Studies using various models, including in vitro and in vivo, have revealed its diverse roles in promoting tumor growth, modulating immune responses, and affecting drug resistance in different cancer types, highlighting its potential as a therapeutic target.
References：
1. Wang, Shuai, Huang, Tengfei, Wu, Qiulian, Placantonakis, Dimitris G, Rich, Jeremy N. 2024. Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation. In The Journal of clinical investigation, 134, . doi:10.1172/JCI176851. https://pubmed.ncbi.nlm.nih.gov/39545414/
2. Liang, Huaiyuan, Yang, Chunguang, Zeng, Ruijiang, Yan, Binyuan, Jin, Xin. 2023. Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2302368. doi:10.1002/advs.202302368. https://pubmed.ncbi.nlm.nih.gov/37949681/
3. Wahab, Muhammad Aamir, Del Gaudio, Nunzio, Gargiulo, Biagio, Altucci, Lucia, Conte, Mariarosaria. 2024. Exploring the Role of CBX3 as a Potential Therapeutic Target in Lung Cancer. In Cancers, 16, . doi:10.3390/cancers16173026. https://pubmed.ncbi.nlm.nih.gov/39272883/
4. Chen, Jiasheng, Lin, Yuxin, Zheng, Shukai, Tang, Shijie, Zhong, Xiaoping. 2023. CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity. In Journal of translational medicine, 21, 600. doi:10.1186/s12967-023-04478-9. https://pubmed.ncbi.nlm.nih.gov/37674204/
5. Bai, Xiaoming, Duan, Tinghong, Shao, Jiaofang, Zhou, Jin-Yong, Pan, Jinshun. 2025. CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. In Oncogene, , . doi:10.1038/s41388-025-03337-9. https://pubmed.ncbi.nlm.nih.gov/40089640/
6. Zhang, Pan, Yang, Xiaoyan, Zha, Zhongming, Zhang, Guoqiang, Li, Guotao. 2022. CBX3 regulated by miR-139 promotes the development of HCC by regulating cell cycle progression. In Cell cycle (Georgetown, Tex.), 21, 1740-1752. doi:10.1080/15384101.2022.2068329. https://pubmed.ncbi.nlm.nih.gov/35471148/
7. Peng, Wen, Shi, Shuang, Zhong, Jiacheng, Zhong, Dong, Cui, Hongjuan. 2022. CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression. In Oncogene, 41, 3051-3063. doi:10.1038/s41388-022-02296-9. https://pubmed.ncbi.nlm.nih.gov/35459780/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.