C57BL/6JCya-Ccnd1em1flox/Cya
Common Name:
Ccnd1-flox
Product ID:
S-CKO-01587
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ccnd1-flox
Strain ID
CKOCMP-12443-Ccnd1-B6J-VA
Gene Name
Product ID
S-CKO-01587
Gene Alias
CycD1; Cyl-1; PRAD1; bcl-1; cD1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ccnd1em1flox/Cya mice (Catalog S-CKO-01587) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000093962
NCBI RefSeq
NM_007631
Target Region
Exon 2~3
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Ccnd1, which encodes the protein cyclin D1, is responsible for regulating the G1 to S phase transition in the cell cycle [3]. It is involved in cell cycle regulation and has been shown to play a role in immune response as well [2].
In cancer research, multiple studies have explored its significance. In gastric cancer, circNFATC3 promotes cell proliferation by binding to IGF2BP3, enhancing CCND1 mRNA stability [1]. In breast cancer, CCND1 amplification is significantly associated with positive estrogen receptor status, cyclin D1 overexpression, shorter recurrence-free survival (RFS) and overall survival (OS). In endocrine-therapy-treated patients, it also predicts shorter RFS and OS [3]. In endometrial cancer, CCND1 is overexpressed and may contribute to lymph node metastasis through promoting autophagy [4]. In low-grade glioma, CCND1 is a prognosis-related gene, and high-expression levels are beneficial for survival in advanced cases [2].
In conclusion, Ccnd1 is a key regulator of the cell cycle. Its dysregulation is associated with various cancers, including gastric, breast, endometrial, and low-grade glioma. Research on Ccnd1 provides insights into the mechanisms of cancer development and progression, potentially guiding the development of new therapeutic strategies for these malignancies.
References：
1. Yang, Feifei, Ma, Qiang, Huang, Bo, Li, Wei, Xiao, Bin. 2023. CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. In Journal of translational medicine, 21, 402. doi:10.1186/s12967-023-04235-y. https://pubmed.ncbi.nlm.nih.gov/37340423/
2. Zhao, Kun, Zhang, Hui, Lin, Jianyang, Wei, Wenxiang, Wang, Yuanwei. 2024. Radiomic Prediction of CCND1 Expression Levels and Prognosis in Low-grade Glioma Based on Magnetic Resonance Imaging. In Academic radiology, 31, 4595-4610. doi:10.1016/j.acra.2024.03.031. https://pubmed.ncbi.nlm.nih.gov/38824087/
3. Jeffreys, Sarah A, Becker, Therese M, Khan, Sarah, de Souza, Paul, Powter, Branka. 2022. Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis. In Frontiers in endocrinology, 13, 895729. doi:10.3389/fendo.2022.895729. https://pubmed.ncbi.nlm.nih.gov/35784572/
4. Su, Yi, Zhou, Haonan, Ma, Zhao, Liu, Jing, Li, Chen. 2023. CCND1-Induced Autophagy Contributes to Lymph Node Metastasis in Endometrial Cancer. In Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 55, 413-419. doi:10.1055/a-2044-9227. https://pubmed.ncbi.nlm.nih.gov/37019147/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen