C57BL/6JCya-Cd83em1flox/Cya
Common Name
Cd83-flox
Product ID
S-CKO-01643
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12522-Cd83-B6J-VA
Status
When using this mouse strain in a publication, please cite “Cd83-flox Mouse (Catalog S-CKO-01643) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Cd83-flox
Strain ID
CKOCMP-12522-Cd83-B6J-VA
Gene Name
Product ID
S-CKO-01643
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
CD83 antigen
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 13 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000015540
NCBI Transcript ID
NM_009856
Target Region
Exon 3
Size of Effective Region
~2.2 kb
Overview of Gene Research
Cd83, a member of the immunoglobulin (Ig) superfamily, is expressed in membrane-bound or soluble forms. It is highly expressed by mature dendritic cells (DCs), and also on activated B cells and T cells. Cd83 is involved in regulating the immune responses, playing a role in monitoring and resolving inflammatory reactions, as well as in lymphocyte maturation, activation and homeostasis [1,2,3,7].
In immune thrombocytopenia (ITP), ITP patients showed higher CD83 expression than healthy controls. Down-regulation of DC-CD83 inhibited CD4+ T cell proliferation, while over-expression promoted it. siRNA-CD83 regulated cytokine secretion and Tregs expression, reversing Th1/Th2 and Th17/Tregs polarization, indicating its important role in ITP pathogenesis [4].
In experimental autoimmune uveitis (EAU), CD83+ B cells, the main sources of sCD83, alleviated EAU symptoms by decreasing T cells and DCs in the eyes and lymph nodes, and by inhibiting DCs through sCD83 [5]. Also, sCD83 modulates human-monocyte-derived macrophages toward an alternative phenotype, function, and metabolism, increasing the expression of inhibitory molecules and down-regulating pro-inflammatory pathways [6].
In conclusion, Cd83 is crucial for immune regulation. Findings from various disease-related studies, such as in ITP and EAU, demonstrate its role in modulating immune responses and cell functions. These insights help understand the underlying immunological mechanisms and may provide potential therapeutic strategies for related diseases.
References：
1. Riaz, Bushra, Islam, S M Shamsul, Ryu, Hye Myung, Sohn, Seonghyang. 2023. CD83 Regulates the Immune Responses in Inflammatory Disorders. In International journal of molecular sciences, 24, . doi:10.3390/ijms24032831. https://pubmed.ncbi.nlm.nih.gov/36769151/
2. Li, Ziduo, Ju, Xinsheng, Silveira, Pablo A, Hart, Derek N J, Clark, Georgina J. 2019. CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential. In Frontiers in immunology, 10, 1312. doi:10.3389/fimmu.2019.01312. https://pubmed.ncbi.nlm.nih.gov/31231400/
3. Grosche, Linda, Knippertz, Ilka, König, Christina, Steinkasserer, Alexander, Lechmann, Matthias. 2020. The CD83 Molecule - An Important Immune Checkpoint. In Frontiers in immunology, 11, 721. doi:10.3389/fimmu.2020.00721. https://pubmed.ncbi.nlm.nih.gov/32362900/
4. Wang, Xiuli, Zhou, Qiyuan, Yang, Wen, Zhou, Yongchun, Zhou, Zeping. 2024. The role of CD83 in the pathogenesis of immune thrombocytopenia. In Hematology (Amsterdam, Netherlands), 29, 2372482. doi:10.1080/16078454.2024.2372482. https://pubmed.ncbi.nlm.nih.gov/38994874/
5. Feng, Meng, Wang, Xin, Zhou, Shuping, Wei, Xunbin, Lin, Wei. 2023. CD83+ B cells alleviate uveitis through inhibiting DCs by sCD83. In Immunology, 170, 134-153. doi:10.1111/imm.13654. https://pubmed.ncbi.nlm.nih.gov/37137669/
6. Peckert-Maier, Katrin, Wild, Andreas B, Sprißler, Laura, Steinkasserer, Alexander, Royzman, Dmytro. 2023. Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism. In Frontiers in immunology, 14, 1293828. doi:10.3389/fimmu.2023.1293828. https://pubmed.ncbi.nlm.nih.gov/38162675/
7. Breloer, Minka, Fleischer, Bernhard. 2008. CD83 regulates lymphocyte maturation, activation and homeostasis. In Trends in immunology, 29, 186-94. doi:10.1016/j.it.2008.01.009. https://pubmed.ncbi.nlm.nih.gov/18329338/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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