C57BL/6JCya-Cebpgem1flox/Cya
Common Name:
Cebpg-flox
Product ID:
S-CKO-01696
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cebpg-flox
Strain ID
CKOCMP-12611-Cebpg-B6J-VA
Gene Name
Product ID
S-CKO-01696
Gene Alias
C/EBP[g]; C/EBPgamma; GPE1-BP; Gpe1bp; Ig/EBP
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cebpgem1flox/Cya mice (Catalog S-CKO-01696) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000130491
NCBI RefSeq
NM_009884
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Cebpg, also known as CCAAT enhancer binding protein gamma, is a gene implicated in myeloid differentiation and plays critical roles in various physiological and pathological processes. It is involved in pathways such as PI3K-AKT signaling and is associated with the regulation of genes related to antioxidant, DNA repair, and cell cycle processes [2,3,4].
In ovarian cancer, knockdown of Cebpg inhibits cancer progression and reveals its role in suppressing ferroptosis through transcriptional control of SLC7A11 [1]. In acute myeloid leukemia, shRNA-mediated down-regulation of Cebpg shows that it promotes cell proliferation by activating EIF4EBP1 [2]. In esophageal squamous cell carcinoma, Cebpg significantly promotes cell proliferation and migration by activating the PI3K-AKT signaling pathway [3].
In conclusion, Cebpg is a key regulator in multiple diseases including ovarian cancer, acute myeloid leukemia, and esophageal squamous cell carcinoma. Loss-of-function experiments in cell lines and animal models have revealed its roles in promoting cancer progression and evading ferroptosis, highlighting its potential as a therapeutic target in these disease areas.
References：
1. Zhang, Xiaoqian, Zheng, Xiaocui, Ying, Xiang, Yin, Yujia, Wang, Xipeng. 2023. CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer. In Journal of translational medicine, 21, 334. doi:10.1186/s12967-023-04136-0. https://pubmed.ncbi.nlm.nih.gov/37210575/
2. Jiang, You, Wu, Shui-Yan, Chen, Yan-Ling, Fang, Fang, Lu, Jun. 2021. CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. In Cancer cell international, 21, 598. doi:10.1186/s12935-021-02305-z. https://pubmed.ncbi.nlm.nih.gov/34743716/
3. Huang, Yongsheng, Lin, Lehang, Shen, Zhuojian, Lu, Daning, Yin, Dong. 2020. CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling. In American journal of cancer research, 10, 3328-3344. doi:. https://pubmed.ncbi.nlm.nih.gov/33163273/
4. Mullins, D'Anna N, Crawford, Erin L, Khuder, Sadik A, Yoon, Youngsook, Willey, James C. 2005. CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. In BMC cancer, 5, 141. doi:. https://pubmed.ncbi.nlm.nih.gov/16255782/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen