C57BL/6JCya-Ccr1em1flox/Cya
Common Name:
Ccr1-flox
Product ID:
S-CKO-01768
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ccr1-flox
Strain ID
CKOCMP-12768-Ccr1-B6J-VA
Gene Name
Product ID
S-CKO-01768
Gene Alias
Cmkbr1; Mip-1a-R
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ccr1em1flox/Cya mice (Catalog S-CKO-01768) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026911
NCBI RefSeq
NM_009912
Target Region
Exon 2
Size of Effective Region
~4.1 kb
Detailed Document
Overview of Gene Research
Ccr1, the CC chemokine receptor 1, is a G protein-linked receptor predominantly expressed in various leukocytes. It binds to CC chemokines like CCL5 (RANTES) and CCL3 (MIP-1alpha), and is involved in regulating inflammatory responses. Ccr1 is essential for monocyte extravasation and transportation during inflammation, and is considered a promising target for anti-inflammatory therapy [1,2].
In multiple myeloma, CCL3 and CCR1 play a central role in the pathogenesis and MM-induced osteolytic bone disease. CCR1 stimulation leads to tumor growth via upregulation of cell adhesion and cytokine secretion, and also modulates the osteoclast/osteoblast balance. Targeting CCR1 with antagonists in murine and humanized mouse models can control tumor burden and prevent osteolysis [3].
In non-alcoholic steatohepatitis (NASH), CCR1 is upregulated. Ccr1-deficient mice (systemic Ccr1-/-and liver macrophage-knockout Ccr1LKD) fed a high-cholesterol and high-fat or methionine/choline-deficient diet showed inhibited NASH-associated hepatic steatosis, inflammation, and fibrosis. CCR1 inhibitor BX471 also effectively suppressed NASH progression in mice, suggesting CCR1 regulates macrophage activation through mTORC1 signaling in NASH [4].
In conclusion, Ccr1 is crucial in inflammatory processes. Its role in multiple myeloma and NASH has been revealed through gene-knockout mouse models. These findings indicate that targeting Ccr1 could be a potential therapeutic approach for these diseases.
References:
1. Tian, Qi, Yan, Ziang, Guo, Yujia, Chen, Zhibiao, Li, Mingchang. 2024. Inflammatory Role of CCR1 in the Central Nervous System. In Neuroimmunomodulation, 31, 173-182. doi:10.1159/000540460. https://pubmed.ncbi.nlm.nih.gov/39116843/
2. Saeki, Toshihiko, Naya, Akira. . CCR1 chemokine receptor antagonist. In Current pharmaceutical design, 9, 1201-8. doi:. https://pubmed.ncbi.nlm.nih.gov/12769747/
3. Vallet, Sonia, Anderson, Kenneth C. 2011. CCR1 as a target for multiple myeloma. In Expert opinion on therapeutic targets, 15, 1037-47. doi:10.1517/14728222.2011.586634. https://pubmed.ncbi.nlm.nih.gov/21609295/
4. Li, Haoran, Pan, Tongtong, Gao, Lingjia, Ding, Chunming, Xu, Liang. 2023. Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis. In Metabolism: clinical and experimental, 151, 155758. doi:10.1016/j.metabol.2023.155758. https://pubmed.ncbi.nlm.nih.gov/38070823/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen