C57BL/6JCya-Ccr2em1flox/Cya
Common Name
Ccr2-flox
Product ID
S-CKO-01771
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12772-Ccr2-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ccr2-flox Mouse (Catalog S-CKO-01771) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ccr2-flox
Strain ID
CKOCMP-12772-Ccr2-B6J-VA
Gene Name
Product ID
S-CKO-01771
Gene Alias
Ckr2, Ccr2a, Ccr2b, Ckr2a, Ckr2b, mJe-r, Cmkbr2, Cc-ckr-2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000055918
NCBI RefSeq
NM_009915
Target Region
Exon 3
Size of Effective Region
~4.0 kb
Overview of Gene Research
Ccr2, namely C-C chemokine receptor 2, is a cell surface receptor belonging to the chemokine receptor superfamily. It is mainly expressed on cells such as monocytes, macrophages, T cells, and neurons, and binds to its ligand, monocyte chemoattractant protein-1 (MCP-1), to participate in the regulation of inflammatory responses and immune cell migration. Activation of Ccr2 can promote the movement of these cells to the inflamed sites, thus playing an important role in inflammation and immune responses. In addition, Ccr2 is also associated with the occurrence and development of various diseases, such as atherosclerosis, tumor metastasis, osteoporosis, and abdominal aortic aneurysm. Therefore, the study of Ccr2 is of great significance for understanding the pathogenesis of diseases and finding new treatment strategies.
According to references, Ccr2 plays an important role in various diseases. For example, in subacute subdural hematoma (SAH), the expression of Ccr2 is upregulated and is closely related to neuroinflammation and neuronal apoptosis. Studies have shown that inhibiting Ccr2 can reduce neuroinflammation, decrease neuronal apoptosis, and improve the prognosis of SAH patients [1]. In addition, Ccr2 is also related to the development of atherosclerosis. Research has found that after acute kidney injury (AKI), CCR2+ bone marrow cells can promote the formation of atherosclerotic plaques [2]. Moreover, Ccr2 gene polymorphism is associated with the severity of ovarian cancer. Studies have found that the CCR2 (+190 G/A) GG genotype is associated with the advanced stage of ovarian cancer, while the A allele is associated with the early stage of ovarian cancer [3]. In addition, Ccr2 gene polymorphism is also associated with the risk of oral squamous cell carcinoma (OSCC). Research has found that the CCR2 V64I gene polymorphism can increase the risk of OSCC [4].
In summary, Ccr2 plays an important role in various diseases, including subacute subdural hematoma, atherosclerosis, ovarian cancer, and oral squamous cell carcinoma. The study of Ccr2 helps to deeply understand the pathogenesis of these diseases and find new treatment strategies.
References:
1. Tian, Qi, Guo, Yujia, Feng, Shi, Zhang, Zhan, Li, Mingchang. 2022. Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway. In Journal of neuroinflammation, 19, 312. doi:10.1186/s12974-022-02676-8. https://pubmed.ncbi.nlm.nih.gov/36566220/
2. Fernandes, Alexandre P, Águeda-Pinto, Ana, Pinheiro, Ana, Rebelo, Hugo, Esteves, Pedro J. 2022. Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events. In Viruses, 14, . doi:10.3390/v14020169. https://pubmed.ncbi.nlm.nih.gov/35215768/
3. Yildirim, Gazi, Attar, Rukset, Gulec-Yilmaz, Seda, Duman, Selvi, Isbir, Turgay. 2017. Association of CCR2 (+190 G/A) Gene Variants and Ovarian Cancer Severity. In Genetic testing and molecular biomarkers, 21, 512-515. doi:10.1089/gtmb.2017.0008. https://pubmed.ncbi.nlm.nih.gov/28650671/
4. Bektas-Kayhan, K, Unur, M, Boy-Metin, Z, Cakmakoglu, B. 2011. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. In Oral diseases, 18, 55-9. doi:10.1111/j.1601-0825.2011.01843.x. https://pubmed.ncbi.nlm.nih.gov/21883707/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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