C57BL/6JCya-Ccr7em1flox/Cya
Common Name:
Ccr7-flox
Product ID:
S-CKO-01774
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ccr7-flox
Strain ID
CKOCMP-12775-Ccr7-B6J-VA
Gene Name
Product ID
S-CKO-01774
Gene Alias
CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7; EBI1; Ebi1h
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ccr7em1flox/Cya mice (Catalog S-CKO-01774) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000103134
NCBI RefSeq
NM_007719
Target Region
Exon 3
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Ccr7, a chemokine receptor, is a G protein-coupled receptor with 7 transmembrane domains. It plays a crucial role in immune cell trafficking, being expressed on various cells like naive T/B cells, central memory T cells, etc. Ccr7, along with its ligands CCL19 and CCL21, is involved in the migration of dendritic cells to T-cell zones in lymph nodes, initiating antigen presentation and T-cell response. It also participates in the CCL21/CCR7 axis, which is associated with autoimmune diseases, cancer metastasis, and other pathological conditions [1,2,4,5].
In autoimmune diseases such as rheumatoid arthritis, sjogren's syndrome, etc., genome-wide association studies have shown a strong link between the CCL21/CCR7 axis and disease severity. Disrupting the CCL21/CCR7 interaction can prevent the migration of CCR7-expressing cells to the site of inflammation and reduce disease severity [1]. In cancer, the CCR7 axis has a dual role. It can contribute to the trafficking of effector cells for anti-tumor immune responses, but also plays a role in tumor cell migration towards the lymphatic system and metastasis [2]. In blood cancers, CCR7 expression often correlates with nodal or spleen involvement [3].
In conclusion, Ccr7 is essential for immune cell migration and the regulation of immune responses. Its role in autoimmune diseases and cancer, as revealed through various studies, highlights its potential as a therapeutic target. Understanding Ccr7's functions through model-based research, especially in the context of these diseases, can provide new strategies for treatment and management.
References:
1. Han, Le, Zhang, Lingling. 2023. CCL21/CCR7 axis as a therapeutic target for autoimmune diseases. In International immunopharmacology, 121, 110431. doi:10.1016/j.intimp.2023.110431. https://pubmed.ncbi.nlm.nih.gov/37331295/
2. Salem, Anwar, Alotaibi, Mashael, Mroueh, Rima, Basheer, Haneen A, Afarinkia, Kamyar. 2020. CCR7 as a therapeutic target in Cancer. In Biochimica et biophysica acta. Reviews on cancer, 1875, 188499. doi:10.1016/j.bbcan.2020.188499. https://pubmed.ncbi.nlm.nih.gov/33385485/
3. Cuesta-Mateos, Carlos, Terrón, Fernando, Herling, Marco. 2021. CCR7 in Blood Cancers - Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target. In Frontiers in oncology, 11, 736758. doi:10.3389/fonc.2021.736758. https://pubmed.ncbi.nlm.nih.gov/34778050/
4. Hong, Wenxiang, Yang, Bo, He, Qiaojun, Wang, Jiajia, Weng, Qinjie. 2022. New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases. In Frontiers in pharmacology, 13, 841687. doi:10.3389/fphar.2022.841687. https://pubmed.ncbi.nlm.nih.gov/35281921/
5. Brandum, Emma Probst, Jørgensen, Astrid Sissel, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene. 2021. Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer. In International journal of molecular sciences, 22, . doi:10.3390/ijms22158340. https://pubmed.ncbi.nlm.nih.gov/34361107/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen