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C57BL/6JCya-Col15a1em1flox/Cya
Common Name:
Col15a1-flox
Product ID:
S-CKO-01805
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Col15a1-flox
Strain ID
CKOCMP-12819-Col15a1-B6J-VA
Gene Name
Col15a1
Product ID
S-CKO-01805
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
12819
Modification
Conditional knockout
Chromosome
4
Phenotype
MGI:88449
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Col15a1em1flox/Cya mice (Catalog S-CKO-01805) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102917
NCBI RefSeq
NM_009928
Target Region
Exon 7
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Col15a1 encodes the alpha chain of collagen XV, a member of the FACIT collagen family [2]. It has anti-angiogenic and anti-tumoral properties and is vital for tissue homeostasis in the liver [2]. COL15A1 also seems to be involved in processes like vasculogenesis, as indicated by its altered expression in endothelial cells with a MAP2K1 mutation related to arteriovenous malformation [3].

In the MMTV-PyMT mouse mammary carcinoma model, inactivation of Col15a1 led to changes in the fibrillar tumour matrix and increased mammary tumour growth, supporting its tumour suppressor function in mammary carcinogenesis [4]. In the context of sarcopenia, Mendelian Randomization analysis suggested that down-regulation of COL15A1 decreased the risk of sarcopenia, indicating its potential as a therapeutic target [1]. In HBV-related HCC, COL15A1 silencing promoted the growth and malignancy of HepG2.2.15 cells, revealing its possible anticancer role [2].

In conclusion, Col15a1 plays crucial roles in multiple biological processes and diseases. Its functions in tumour suppression in breast cancer, as well as its potential relation to sarcopenia and role in HBV-related HCC, have been revealed through in vivo studies using mouse models. These findings contribute to understanding the mechanisms of these diseases and potentially developing new therapeutic strategies.

References:
1. Yin, Kang-Fu, Chen, Ting, Gu, Xiao-Jing, Gao, Xia, Chen, Yong-Ping. 2024. Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for sarcopenia. In Journal of cachexia, sarcopenia and muscle, 15, 1324-1334. doi:10.1002/jcsm.13479. https://pubmed.ncbi.nlm.nih.gov/38644354/
2. Wang, Shuomin, Zhou, Mingran, Xia, Yunhong. 2023. COL15A1 interacts with P4HB to regulate the growth and malignancy of HepG2.2.15 cells. In Biochemical and biophysical research communications, 681, 20-28. doi:10.1016/j.bbrc.2023.09.031. https://pubmed.ncbi.nlm.nih.gov/37742474/
3. Sudduth, Christopher L, Smits, Patrick J, Vivero, Matthew P, Warman, Matthew L, Greene, Arin K. 2023. Arteriovenous malformation Map2k1 mutation affects vasculogenesis. In Scientific reports, 13, 11074. doi:10.1038/s41598-023-35301-6. https://pubmed.ncbi.nlm.nih.gov/37422456/
4. Martínez-Nieto, Guillermo, Heljasvaara, Ritva, Heikkinen, Anne, Pihlajaniemi, Taina, Karppinen, Sanna-Maria. 2021. Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model. In International journal of molecular sciences, 22, . doi:10.3390/ijms22189978. https://pubmed.ncbi.nlm.nih.gov/34576139/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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