Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Crabp2em1flox/Cya
Common Name:
Crabp2-flox
Product ID:
S-CKO-01853
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Crabp2-flox
Strain ID
CKOCMP-12904-Crabp2-B6J-VA
Gene Name
Crabp2
Product ID
S-CKO-01853
Gene Alias
Crabp-2; CrabpII
Background
C57BL/6JCya
NCBI ID
12904
Modification
Conditional knockout
Chromosome
3
Phenotype
MGI:88491
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Crabp2em1flox/Cya mice (Catalog S-CKO-01853) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000005019
NCBI RefSeq
NM_007759
Target Region
Exon 2~4
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
CRABP2, or Cellular retinoic acid-binding protein 2, is involved in retinoid partitioning between different nuclear receptors. It participates in various biological processes, potentially influencing cell proliferation, motility, apoptosis, and immune-related pathways. It is associated with pathways like Wnt/β-catenin, integrin/FAK/AKT, and epithelial-mesenchymal transition (EMT) [3,4,5,6].

In melanoma, high CRABP2 levels predicted poor prognosis in PD-1 inhibitor-treated patients, and it may regulate immunotherapy by influencing cancer-associated fibroblasts (CAFs) infiltration [1]. In endometrial cancer, high CRABP2 expression was related to serous EC, reduced overall survival, advanced stage and grade [2]. In Hu sheep dermal papilla cells, overexpression of CRABP2 facilitated cell proliferation via the Wnt/β-catenin pathway [3]. In thyroid cancer, CRABP2 was associated with recurrence and promoted invasion via the integrin/FAK/AKT pathway [4]. In lung cancer, it promoted metastasis via HuR and integrin β1/FAK/ERK signaling [5]. In serous ovarian cancer cells, it accelerated EMT by promoting TRIM16 methylation via upregulating EZH2 expression [6]. In prostate cancer, it facilitated cell migration and invasion by activating PI3K/AKT and MAPK signaling pathways through upregulating LAMB3 [7]. In human osteoblast cells, overexpression of CRABP2 inhibited dexamethasone-induced apoptosis [8]. In breast cancer, it was identified as an oncogene promoting tumour cell proliferation, migration, and invasion [9].

In conclusion, CRABP2 is involved in multiple biological functions including cell proliferation, apoptosis, invasion, and immune-related processes. Studies on CRABP2, especially through in vivo models, have revealed its significant roles in various cancers such as melanoma, endometrial, thyroid, lung, ovarian, prostate, and breast cancers, providing potential biomarker and therapeutic target implications for these disease areas.

References:
1. Zeng, Shuangshuang, Chen, X I, Yi, Qiaoli, Yan, Yuanliang, Liu, Shao. 2023. CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma. In Oncology research, 32, 261-272. doi:10.32604/or.2023.042345. https://pubmed.ncbi.nlm.nih.gov/38186580/
2. Egan, Donagh, Moran, Bruce, Wilkinson, Michael, le Roux, Carel W, Brennan, Donal J. 2022. CRABP2 - A novel biomarker for high-risk endometrial cancer. In Gynecologic oncology, 167, 314-322. doi:10.1016/j.ygyno.2022.09.020. https://pubmed.ncbi.nlm.nih.gov/36163055/
3. He, Mingliang, Lv, Xiaoyang, Cao, Xiukai, Wang, Shanhe, Sun, Wei. 2023. CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Pathway. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13122033. https://pubmed.ncbi.nlm.nih.gov/37370543/
4. Liu, Chien-Liang, Hsu, Yi-Chiung, Kuo, Chi-Yu, Li, Ying-Syuan, Cheng, Shih-Ping. . CRABP2 Is Associated With Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway. In Endocrinology, 163, . doi:10.1210/endocr/bqac171. https://pubmed.ncbi.nlm.nih.gov/36240291/
5. Wu, Jun-I, Lin, Yi-Pei, Tseng, Chien-Wei, Chen, Hui-Jane, Wang, Lu-Hai. 2019. Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling. In Scientific reports, 9, 845. doi:10.1038/s41598-018-37443-4. https://pubmed.ncbi.nlm.nih.gov/30696915/
6. Xie, Tingting, Tan, Minghua, Gao, Yang, Yang, Hong. 2022. CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression. In Environmental toxicology, 37, 1957-1967. doi:10.1002/tox.23542. https://pubmed.ncbi.nlm.nih.gov/35442568/
7. Wang, Rui, Liao, Zhaoping, Liu, Chunhua, Cheng, Gang, Li, Sanlian. . CRABP2 promotes cell migration and invasion by activating PI3K/AKT and MAPK signalling pathways via upregulating LAMB3 in prostate cancer. In Journal of biochemistry, 176, 313-324. doi:10.1093/jb/mvae052. https://pubmed.ncbi.nlm.nih.gov/39038078/
8. Zhang, Haiping, Yu, Ziliang, Sun, Farui, Jin, Jin. 2021. Overexpression of CRABP2 inhibits dexamethasone-induced apoptosis in human osteoblast cells. In Journal of orthopaedic surgery and research, 16, 272. doi:10.1186/s13018-021-02386-6. https://pubmed.ncbi.nlm.nih.gov/33879199/
9. Mei, Jie, Cai, Yun, Chen, Lingyan, Pan, Xiang, Zhang, Yan. 2023. The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer. In British journal of cancer, 129, 1645-1657. doi:10.1038/s41416-023-02432-6. https://pubmed.ncbi.nlm.nih.gov/37715025/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest