C57BL/6JCya-Crcpem1flox/Cya
Common Name:
Crcp-flox
Product ID:
S-CKO-01856
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Crcp-flox
Strain ID
CKOCMP-12909-Crcp-B6J-VA
Gene Name
Product ID
S-CKO-01856
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Crcpem1flox/Cya mice (Catalog S-CKO-01856) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026608
NCBI RefSeq
NM_007761
Target Region
Exon 2~3
Size of Effective Region
~3.5 kb
Detailed Document
Overview of Gene Research
There is no information directly related to the gene Crcp in the provided references. It's possible that the references are either misaligned with the request or the name Crcp is used in a non-gene context within them. Usually, a gene's function, associated pathways, and importance can be determined through genetic models like KO/CKO mouse models in in vivo studies. These models help in understanding how the absence or modification of the gene affects specific biological processes and disease conditions.
However, among the references, the closest related concept might be the critical closing pressure (CrCP) of the cerebral circulation [1,2,3,4]. CrCP indicates the arterial blood pressure value at which cerebral blood flow approaches zero. It can be influenced by parameters such as intracranial pressure and active wall tension. Different methods can be used to calculate CrCP, and changes in CrCP are associated with conditions like cerebral vasospasm after aneurysmal subarachnoid hemorrhage and are related to patient outcomes [3]. In preterm infants, there is a high correlation between observed and calculated CrCP [4]. But this is not related to a gene Crcp.
In conclusion, based on the provided references, no information about the gene Crcp's function, its role in diseases through gene-knockout models or other relevant aspects could be obtained. If Crcp is indeed a gene, further research in relevant databases would be needed to understand its biological functions, associated pathways, and its importance in disease conditions.
References:
1. Panerai, R B. . The critical closing pressure of the cerebral circulation. In Medical engineering & physics, 25, 621-32. doi:. https://pubmed.ncbi.nlm.nih.gov/12900178/
2. Kaczmarska, Katarzyna, Kasprowicz, Magdalena, Grzanka, Antoni, Czosnyka, Marek, Czosnyka, Zofia. . Critical Closing Pressure During a Controlled Increase in Intracranial Pressure. In Acta neurochirurgica. Supplement, 126, 133-137. doi:10.1007/978-3-319-65798-1_28. https://pubmed.ncbi.nlm.nih.gov/29492548/
3. Varsos, Georgios V, Budohoski, Karol P, Czosnyka, Marek, Varsos, Vassilis G, Smielewski, Peter. 2014. Cerebral vasospasm affects arterial critical closing pressure. In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35, 285-91. doi:10.1038/jcbfm.2014.198. https://pubmed.ncbi.nlm.nih.gov/25465041/
4. Elizondo, Leah I, Rios, Danielle R, Vu, Eric, Brady, Ken M, Rhee, Christopher J. 2019. Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants. In Pediatric research, 86, 242-246. doi:10.1038/s41390-019-0403-y. https://pubmed.ncbi.nlm.nih.gov/31003233/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen