C57BL/6JCya-Creb1em1flox/Cya
Common Name
Creb1-flox
Product ID
S-CKO-01857
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12912-Creb1-B6J-VA
When using this mouse strain in a publication, please cite “Creb1-flox Mouse (Catalog S-CKO-01857) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Creb1-flox
Strain ID
CKOCMP-12912-Creb1-B6J-VA
Gene Name
Product ID
S-CKO-01857
Gene Alias
Creb, Creb-1, 2310001E10Rik, 3526402H21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000190348
NCBI RefSeq
NM_009952
Target Region
Exon 5
Size of Effective Region
~1.4 kb
Overview of Gene Research
Creb1, also known as cAMP responsive element binding protein 1, is a key transcription factor. It mediates transcriptional responses to diverse growth factors and stress signals. It is involved in various pathways, and has been shown to play a critical role in the development and progression of tumors [2].
In skin inflammation, CREB1 drives the development of CXCR4hi neutrophils. Blockade of CXCR4hi neutrophils through CXCR4 or CXCL12 inhibition, which are related to CREB1-regulated CXCR4 expression, leads to suppression of immune responses in mouse models [1]. In non-small cell lung cancer, knockdown of CREB1 sensitizes cells to ferroptosis inducers, and high expression of CREB1 is associated with poor prognosis [4]. In cervical cancer, depletion of CREB1 or inhibition of its activity reduces cell proliferation and migration in HPV+ cervical cancer cell lines [3].
In conclusion, Creb1 is a crucial transcription factor involved in multiple biological processes and disease conditions. Studies using gene-knockdown or-inhibition models have revealed its role in skin inflammation, non-small cell lung cancer, and cervical cancer, among others, providing insights into potential therapeutic strategies for these diseases.
References：
1. Chen, Jiaoling, Bai, Yaxing, Xue, Ke, Wang, Gang, Shao, Shuai. 2023. CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients. In Nature communications, 14, 5894. doi:10.1038/s41467-023-41484-3. https://pubmed.ncbi.nlm.nih.gov/37736772/
2. Wang, Ya-Wen, Chen, Xu, Ma, Rong, Gao, Peng. 2016. Understanding the CREB1-miRNA feedback loop in human malignancies. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37, 8487-502. doi:10.1007/s13277-016-5050-x. https://pubmed.ncbi.nlm.nih.gov/27059735/
3. Li, Yigen, Patterson, Molly R, Morgan, Ethan L, Wang, Miao, Macdonald, Andrew. . CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation. In Journal of medical virology, 95, e29025. doi:10.1002/jmv.29025. https://pubmed.ncbi.nlm.nih.gov/37565725/
4. Shan, Guangyao, Bi, Guoshu, Zhao, Guangyin, Fan, Hong, Zhan, Cheng. 2023. Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer. In Respiratory research, 24, 277. doi:10.1186/s12931-023-02567-3. https://pubmed.ncbi.nlm.nih.gov/37957645/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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