Csf2rb2, also known as Il3r, is the β chain cytokine receptor. It is involved in cytokine-mediated signaling pathways, which are crucial for various biological processes such as hematopoiesis [1,2]. In hematopoiesis, it likely has a significant impact on the regulation of cell proliferation, differentiation, and apoptosis within the hematopoietic system.

In a study, conditional disruption of RBP-J, a transcription factor of canonical Notch signaling, increased irradiation sensitivity in mice. Activation of Notch signaling with the endothelial cell-targeted soluble Dll1 Notch ligand mD1R promoted bone marrow recovery after irradiation. The β chain cytokine receptor Csf2rb2 was identified as a downstream molecule of Notch signaling in hematopoietic cells. mD1R improved hematopoietic recovery through up-regulation of the hematopoietic expression of Csf2rb2 [1]. Another study showed that in Rcor1-deficient erythroid progenitors, the Csf2rb gene (which codes for a receptor implicated in myeloid cytokine signaling) was highly induced, and these progenitors exhibited CSF2-dependent phospho-Stat5 hypersensitivity. Blocking this pathway could partially reduce myeloid colony formation by Rcor1-deficient erythroid progenitors [2].

In conclusion, Csf2rb2 is essential in hematopoiesis, and its regulation is associated with the recovery of bone marrow after irradiation and the proper differentiation of erythroid progenitors. The use of mouse models, such as those with disrupted Notch signaling or Rcor1 deletion, has provided valuable insights into the role of Csf2rb2 in these processes, which may have implications for understanding and treating conditions related to bone marrow suppression and abnormal hematopoiesis.