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C57BL/6JCya-Ctf1em1flox/Cya
Common Name:
Ctf1-flox
Product ID:
S-CKO-01932
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ctf1-flox
Strain ID
CKOCMP-13019-Ctf1-B6J-VA
Gene Name
Ctf1
Product ID
S-CKO-01932
Gene Alias
CT-1
Background
C57BL/6JCya
NCBI ID
13019
Modification
Conditional knockout
Chromosome
7
Phenotype
MGI:105115
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ctf1em1flox/Cya mice (Catalog S-CKO-01932) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047393
NCBI RefSeq
NM_007795
Target Region
Exon 2
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ctf1, also known as cardiotrophin 1, is involved in multiple biological processes. It activates autophagy in fibroblasts and carcinoma-associated fibroblasts (CAFs) through stimulating phosphorylation and nuclear translocation of STAT3, and is associated with pathways like AMPK and ULK1 activation. It plays a key role in tumor-stroma interactions, fibroblast activation, and cancer metastasis [1]. In the context of glioma, it may be related to tumor progression pathways such as IL2_STAT5, P53, and IL6_JAK_STAT3 signaling pathways, and is associated with immune cell infiltration [2].

In breast cancer, tumor-derived Ctf1 promotes breast cancer cell migration, invasion, and metastasis in an autophagy-dependent manner [1]. In glioma, its high expression is associated with poorer survival, advanced grades, and is an independent risk factor. Also, in glioma, it shows associations with drug sensitivity and immune infiltration [2,5]. Exosomes from Ctf1-modified bone marrow stem cells can promote endometrial regeneration and restore fertility, likely through upregulating the JAK/PI3K/mTOR/STAT3 signaling pathways [3]. In the skin, Ctf1-IL6ST signaling from dermal papilla to endothelial cells promotes angiogenesis during aging [4].

In summary, Ctf1 is crucial in various biological processes and disease conditions. Its role in promoting cancer-related events like metastasis in breast cancer and its associations with prognosis and immune microenvironment in glioma are significant. Also, its potential in endometrial regeneration and angiogenesis in the skin showcases its diverse functions. The study of Ctf1 using various models helps in understanding disease mechanisms and potential therapeutic targets.

References:
1. Akkoc, Yunus, Dalci, Kubilay, Karakas, Hacer Ezgi, Dogan-Ekici, A Isin, Gozuacik, Devrim. 2022. Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. In Autophagy, 19, 306-323. doi:10.1080/15548627.2022.2090693. https://pubmed.ncbi.nlm.nih.gov/35722965/
2. He, Jiakai, Guo, Jiayin, Sun, Pengfei. 2024. Prognostic value of CTF1 in glioma and its role in the tumor microenvironment. In Translational cancer research, 13, 6862-6879. doi:10.21037/tcr-24-1258. https://pubmed.ncbi.nlm.nih.gov/39816535/
3. Zhu, Qianqian, Tang, Shengluan, Zhu, Yanwen, Huang, Jialyu, Lin, Jiaying. 2022. Exosomes Derived From CTF1-Modified Bone Marrow Stem Cells Promote Endometrial Regeneration and Restore Fertility. In Frontiers in bioengineering and biotechnology, 10, 868734. doi:10.3389/fbioe.2022.868734. https://pubmed.ncbi.nlm.nih.gov/35497344/
4. Zhou, Siyi, Li, Zeming, Li, Xinzhu, Chuong, Cheng-Ming, Lei, Mingxing. 2024. Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging. In Journal of advanced research, 70, 339-353. doi:10.1016/j.jare.2024.05.006. https://pubmed.ncbi.nlm.nih.gov/38718895/
5. Cai, Hongqing, Tian, Shen, Liu, Angsi, Wan, Jinghai, Li, Sai. 2025. Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma. In European journal of medical research, 30, 17. doi:10.1186/s40001-024-02192-w. https://pubmed.ncbi.nlm.nih.gov/39780198/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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