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C57BL/6JCya-Drd1em1flox/Cya
Common Name:
Drd1-flox
Product ID:
S-CKO-02090
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Drd1-flox
Strain ID
CKOCMP-13488-Drd1-B6J-VA
Gene Name
Drd1
Product ID
S-CKO-02090
Gene Alias
C030036C15Rik; Drd-1; Drd1a; Gpcr15
Background
C57BL/6JCya
NCBI ID
13488
Modification
Conditional knockout
Chromosome
13
Phenotype
MGI:99578
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Drd1em1flox/Cya mice (Catalog S-CKO-02090) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021932
NCBI RefSeq
NM_010076
Target Region
Exon 2
Size of Effective Region
~1.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Drd1, encoding the dopamine D1 receptor, is a crucial component of the dopaminergic system. Dopamine receptors, including D1-and D2-like receptors, are significant therapeutic targets in neurological syndromes, as well as cardiovascular and kidney diseases [1]. DRD1 is highly expressed in the central nervous system, especially in the striatum, and is involved in various biological processes, such as motor control, learning, and reward-related behaviors. It couples with the Gs heterotrimer, and its signaling is essential for multiple downstream pathways [1].

In the context of diseases, several studies have explored the role of Drd1. In glioblastoma (GBM), DRD1 contributes to invasion and progression by regulating c-Myc entry into the nucleus, affecting the transcription of the UHRF1 gene. The DRD1 inhibitor SKF83566 suppresses GBM stemness and invasion [2]. In Parkinson's disease, impaired DRD1 signaling may contribute to disturbed motor function as it modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons [3]. In non-small cell lung cancer (NSCLC), DRD1 acts as a negative regulator of disease progression, inhibiting cell proliferation by reducing EGFR activation and PD-L1 expression [4]. In addition, loss-of-function variants in DRD1 are associated with infantile parkinsonism-dystonia [5].

In conclusion, Drd1 plays essential roles in motor control, neural plasticity, and disease-related processes such as cancer progression and neurodegenerative diseases. Studies using various models, including in vitro and in vivo experiments, have provided insights into its functions. Understanding Drd1 is crucial for developing therapeutic strategies for multiple diseases related to the dopaminergic system.

References:
1. Xiao, Peng, Yan, Wei, Gou, Lu, Yu, Xiao, Shao, Zhenhua. 2021. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. In Cell, 184, 943-956.e18. doi:10.1016/j.cell.2021.01.028. https://pubmed.ncbi.nlm.nih.gov/33571432/
2. Xue, Zhiyi, Zhang, Yan, Zhao, Ruiqi, Wang, Jian, Zhou, Wenjing. 2024. The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions. In Journal of experimental & clinical cancer research : CR, 43, 25. doi:10.1186/s13046-024-02947-7. https://pubmed.ncbi.nlm.nih.gov/38246990/
3. Andreska, Thomas, Lüningschrör, Patrick, Wolf, Daniel, Stigloher, Christian, Sendtner, Michael. 2023. DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons. In Cell reports, 42, 112575. doi:10.1016/j.celrep.2023.112575. https://pubmed.ncbi.nlm.nih.gov/37252844/
4. Grant, Christopher E, Flis, Amy L, Toulabi, Leila, Sheppard, Heather, Ryan, Bríd M. 2024. DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC. In Molecular oncology, 18, 1631-1648. doi:10.1002/1878-0261.13608. https://pubmed.ncbi.nlm.nih.gov/38572507/
5. Reid, Kimberley M, Steel, Dora, Nair, Sanjana, Topf, Maya, Kurian, Manju A. 2023. Loss-of-Function Variants in DRD1 in Infantile Parkinsonism-Dystonia. In Cells, 12, . doi:10.3390/cells12071046. https://pubmed.ncbi.nlm.nih.gov/37048120/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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